SCHEMBL3424898

SCHEMBL3424898

NC(CCC(=O)O)C[C@@H](N)C(=O)O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM8 O00222 2/20 0.67
GRM6 O15303 2/20 0.67
GRM7 Q14831 2/20 0.67
GRM4 Q14833 2/20 0.67
GRIK1 P39086 2/20 0.67
SLC1A3 P43003 2/20 0.67
SLC1A2 P43004 2/20 0.67
SLC1A1 P43005 2/20 0.67
GRIK2 Q13002 2/20 0.67
GRIN2D O15399 1/20 0.67
GRIN3B O60391 1/20 0.67
GSR P00390 1/20 0.67
CYP1A2 P05177 1/20 0.67
GRM5 P41594 1/20 0.67
GRIA1 P42261 1/20 0.67
GRIA2 P42262 1/20 0.67
GRIA3 P42263 1/20 0.67
GRIA4 P48058 1/20 0.67
GRIN1 Q05586 1/20 0.67
GRIN2A Q12879 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9309394 1.00 GRM8 (0.67) GRM8GRM6GRM7GRM4GRIK1
SCHEMBL2859864 0.85 ENPEP (0.60) GRM8GRM6GRM7GRM4GRIK1
SCHEMBL28267787 0.82 GRM8 (0.67) GRM8GRM6GRM7GRM4GRIK1
SCHEMBL27399381 0.81 GGT1 (0.54) GRM8GRM6GRM7GRM4GRIK1
D-Glutamate SCHEMBL410241 0.80 GRM8 (1.00) GRM8GRM6GRM7GRM4GRIK1
D-Glutamate SCHEMBL1330824 0.80 GRM8 (1.00) GRM8GRM6GRM7GRM4GRIK1
D-Glutamate SCHEMBL1330484 0.80 GRM8 (1.00) GRM8GRM6GRM7GRM4GRIK1
D-Glutamate SCHEMBL2201 0.80 GRM8 (1.00) GRM8GRM6GRM7GRM4GRIK1
D-Glutamate SCHEMBL17127348 0.80 GRM8 (1.00) GRM8GRM6GRM7GRM4GRIK1
Glutamic Acid SCHEMBL1554237 0.80 GRM8 (1.00) GRM8GRM6GRM7GRM4GRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3391876-B1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL SDG INC (US) 2021-03-10 EP disclosed
US-8846053-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2014-09-30 US disclosed
US-20130267462-A1 Lipid Construct for Delivery of Insulin to a Mammal SDG, INC. 2013-10-10 US disclosed
US-20100310599-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. 2010-12-09 US disclosed
US-20100129428-A1 SUPRA MOLECULAR CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL SDG, INC. 2010-05-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100129428-A1 SUPRA MOLECULAR CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL HAVCR2, IFNAR1, IFNG GRM8 3134/4885GRM6 2240/4885GRM7 2915/4885
US-20100310599-A1 Orally Bioavailable Lipid-Based Constructs FABP2, LIPC, FABP6 GRM8 2828/4885GRM6 791/4885GRM7 2159/4885
US-20130267462-A1 Lipid Construct for Delivery of Insulin to a Mammal INSR, IAPP, GPR119 GRM8 2617/4885GRM6 1703/4885GRM7 1668/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.