Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | RXRB | P28702 | 2/20 | 0.43 |
| ▸ | RXRG | P48443 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE9A | O76083 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | GRK6 | P43250 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3431568 | 0.90 | RXRA (0.44) | RXRARXRBRXRGCTSKPDE5A | |
| SCHEMBL3431683 | 0.87 | RXRA (0.40) | RXRARXRBRXRGCTSKPDE5A | |
| SCHEMBL3346056 | 0.75 | S1PR1 (0.41) | RXRARXRBRXRGCTSKPDE5A | |
| SCHEMBL3429558 | 0.73 | CTSA (0.40) | PARP1PIN1GRK6GRIN1GRIN2B | |
| SCHEMBL3346289 | 0.73 | PDE5A (0.40) | PDE5APDE9APTGDR2FFAR1FFAR4 | |
| SCHEMBL3430892 | 0.71 | FFAR4 (0.44) | PDE5APDE9APTGDR2FFAR1FFAR4 | |
| SCHEMBL3346086 | 0.71 | PTGER4 (0.44) | RXRARXRBRXRGPARP1GRIN1 | |
| SCHEMBL3347691 | 0.67 | FFAR4 (0.40) | RXRARXRBPDE5AFFAR1GRIN1 | |
| SCHEMBL3346903 | 0.67 | GRIN2B (0.36) | PDE5APDE9APARP1GRIN1GRIN2B | |
| SCHEMBL3346002 | 0.67 | GRIN2D (0.41) | RXRARXRBFFAR1GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053757-A1 | 2 -OXOQUINOXALIN BLOCKERS OF THE LATE SODIUM CHANNEL | GILEAD PALO ALTO, INC. (US) | 2010-05-14 | — | — | WO | disclosed |