Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.60 |
| ▸ | ALPI | P09923 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | XIAP | P98170 | 1/20 | 0.55 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.50 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | SLC15A1 | P46059 | 2/20 | 0.47 |
| ▸ | ANPEP | P15144 | 1/20 | 0.47 |
| ▸ | LAP3 | P28838 | 1/20 | 0.47 |
| ▸ | CPA1 | P15085 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474169 | 1.00 | EPHX1 (0.60) | EPHX1ALPIPKMPTGS1XIAP | |
| SCHEMBL414455 | 1.00 | EPHX1 (0.60) | EPHX1ALPIPKMPTGS1XIAP | |
| SCHEMBL8995089 | 0.94 | ALPI (0.55) | EPHX1ALPIPKMPTGS1XIAP | |
| SCHEMBL7180095 | 0.85 | EPHX1 (0.44) | EPHX1ALPIPKMPTGS1XIAP | |
| SCHEMBL180366 | 0.82 | CYP1A2 (0.64) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL9578908 | 0.82 | CYP1A2 (0.58) | EPHX1ALPIPKMPTGS1XIAP | |
| SCHEMBL8953468 | 0.82 | CYP1A2 (0.64) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL57558 | 0.82 | CYP1A2 (0.64) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL197252 | 0.82 | CYP1A2 (0.64) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL27181805 | 0.81 | SLC7A5 (0.55) | EPHX1SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117460722-A | Nicotinamide RIPK1 inhibitors | 艾伯维公司 | 2024-01-26 | — | — | CN | disclosed |
| EP-4301744-A1 | NICOTINAMIDE RIPK1 INHIBITORS | AbbVie Inc. (US) | 2024-01-10 | — | — | EP | disclosed |
| US-11767310-B2 | Nicotinamide RIPK1 inhibitors | ABBVIE INC. (US) | 2023-09-26 | — | — | US | disclosed |
| US-20230127127-A1 | NICOTINAMIDE RIPK1 INHIBITORS | ABBVIE INC. | 2023-04-27 | — | — | US | disclosed |
| WO-2023018643-A1 | NICOTINAMIDE RIPK1 INHIBITORS | ABBVIE INC. (US) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023018643-A1 | NICOTINAMIDE RIPK1 INHIBITORS | ABBVIE INC. (US) | 2023-02-16 | — | — | WO | disclosed |
| EP-3793565-B1 | MCL-1 INHIBITORS | GILEAD SCIENCES INC (US) | 2022-01-05 | — | — | EP | disclosed |
| US-10258045-B2 | Molecules having pesticidal utility and intermediates, compositions and processes related thereto | DOW AGROSCIENCES LLC (US) | 2019-04-16 | — | — | US | disclosed |
| US-20180098541-A1 | MOLECULES HAVEING PESTICIDAL UTILIY AND INTERMEDIATES, COMPOSITIONS AND PROCESSES RELATED THERETO | DOW AGROSCIENCES LLC (US) | 2018-04-12 | — | — | US | disclosed |
| US-7759514-B2 | Mu opioid receptor ligands: methods of use and synthesis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2010-07-20 | — | — | US | disclosed |
| US-20090093534-A1 | Mu opioid receptor ligands: methods of use and synthesis | HARVARD COLLEGE, PRESIDENT AND FELLOWS OF (US) | 2009-04-09 | — | — | US | disclosed |
| US-7223888-B2 | Mu opioid receptor ligands: methods of use and synthesis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-05-29 | — | — | US | disclosed |
| US-20040254225-A1 | Mu opioid receptor ligands: methods of use and synthesis | HARVARD COLLEGE, PRESIDENT AND FELLOWS OF | 2004-12-16 | — | — | US | disclosed |
| WO-2004033414-A1 | MU OPIOID RECEPTOR LIGANDS: METHODS OF USE AND SYNTHESIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2004-04-22 | — | — | WO | disclosed |
| US-4758584-A | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups | CIBA-GEIGY CORPORATION (US) | 1988-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180098541-A1 | MOLECULES HAVEING PESTICIDAL UTILIY AND INTERMEDIATES, COMPOSITIONS AND PROCESSES RELATED THERETO | ACHE, DDT, MLYCD | EPHX1 297/4885ALPI 942/4885PKM 221/4885 |
| US-20040254225-A1 | Mu opioid receptor ligands: methods of use and synthesis | OPRM1, OPRK1, OPRL1 | EPHX1 1980/4885ALPI 4094/4885PKM 2230/4885 |
| US-20090093534-A1 | Mu opioid receptor ligands: methods of use and synthesis | OPRM1, OPRK1, OPRL1 | EPHX1 1980/4885ALPI 4094/4885PKM 2230/4885 |
| US-20230127127-A1 | NICOTINAMIDE RIPK1 INHIBITORS | RIPK1, RIPK2, RIPK4 | EPHX1 1985/4885ALPI 163/4885PKM 2255/4885 |
| US-11767310-B2 | Nicotinamide RIPK1 inhibitors | RIPK1, RIPK2, RIPK4 | EPHX1 1985/4885ALPI 163/4885PKM 2255/4885 |
| US-10258045-B2 | Molecules having pesticidal utility and intermediates, compositions and processes related thereto | ACHE, DDT, MLYCD | EPHX1 256/4885ALPI 3300/4885PKM 472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.