Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 3/20 | 0.41 |
| ▸ | RXRB | P28702 | 3/20 | 0.41 |
| ▸ | RXRG | P48443 | 3/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.41 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1110649 | 0.97 | ALDH1A1 (0.44) | ALDH1A1KDM4EHTTMEN1KMT2A | |
| SCHEMBL3436334 | 0.93 | CNR2 (0.43) | ALDH1A1KDM4ENPSR1TP53RPA1 | |
| SCHEMBL3434336 | 0.90 | RXRA (0.40) | ALDH1A1KDM4EHTTMEN1KMT2A | |
| SCHEMBL3432814 | 0.89 | ALDH1A1 (0.38) | ALDH1A1KDM4EHTTMEN1KMT2A | |
| SCHEMBL3434918 | 0.87 | ALDH1A1 (0.40) | ALDH1A1KDM4EHTTMEN1KMT2A | |
| SCHEMBL3434799 | 0.87 | RPA1 (0.42) | ALDH1A1KDM4EHTTMEN1KMT2A | |
| SCHEMBL3433370 | 0.87 | ALDH1A1 (0.41) | ALDH1A1KDM4EHTTMEN1KMT2A | |
| SCHEMBL1110698 | 0.87 | PPP1CA (0.50) | ALDH1A1KDM4EHTTKMT2ATP53 | |
| SCHEMBL3430227 | 0.86 | ALDH1A1 (0.45) | ALDH1A1HTTTP53RXRARXRB | |
| SCHEMBL3429282 | 0.86 | FAAH (0.49) | ALDH1A1KMT2ATP53SMN1; SMN2RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254885-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AiCuris GmbH & Co. KG (DE) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009115213-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2009-09-24 | — | — | WO | disclosed |