Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | F11 | P03951 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1110649 | 0.94 | ALDH1A1 (0.44) | CNR2ADORA2AALDH1A1KDM4EHPGD | |
| SCHEMBL3434465 | 0.93 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDTP53NPSR1 | |
| SCHEMBL3434266 | 0.91 | PGR (0.39) | CNR2ADORA2AHRH2HRH1ALDH1A1 | |
| SCHEMBL3433402 | 0.89 | CNR2 (0.38) | CNR2ADORA2AHRH2HRH1ALDH1A1 | |
| SCHEMBL3434799 | 0.88 | RPA1 (0.42) | CNR2ADORA2AHRH2HRH1ALDH1A1 | |
| SCHEMBL3432814 | 0.88 | ALDH1A1 (0.38) | ALDH1A1KDM4ETP53NPSR1RPA1 | |
| SCHEMBL3434336 | 0.87 | RXRA (0.40) | CNR2ALDH1A1KDM4EHPGDPDCD1 | |
| SCHEMBL3433370 | 0.84 | ALDH1A1 (0.41) | ALDH1A1KDM4ETP53NPSR1 | |
| SCHEMBL1765264 | 0.83 | CA9 (0.54) | ALDH1A1KDM4EHPGDTLR8TLR7 | |
| SCHEMBL1110698 | 0.81 | PPP1CA (0.50) | ALDH1A1KDM4ETP53FAAHRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254885-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AiCuris GmbH & Co. KG (DE) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009115213-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2009-09-24 | — | — | WO | disclosed |