SCHEMBL344569

SCHEMBL344569

C=C[C@H]1CCN(C(=O)OC(C)(C)C)C1

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.48
RECQL P46063 1/20 0.46
EPHX1 P07099 1/20 0.46
MAPT P10636 2/20 0.44
MEN1 O00255 1/20 0.44
ALDH1A1 P00352 1/20 0.44
KMT2A Q03164 1/20 0.44
USP2 O75604 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
GPR119 Q8TDV5 4/20 0.43
NR1H2 P55055 1/20 0.42
KDM4E B2RXH2 1/20 0.42
THRB P10828 1/20 0.42
PTPN2 P17706 1/20 0.42
PTPN1 P18031 1/20 0.42
PTPN6 P29350 1/20 0.42
PIK3CD O00329 1/20 0.41
USP30 Q70CQ3 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL344797 1.00 HPGD (0.48) HPGDRECQLEPHX1MAPTMEN1
SCHEMBL1279722 1.00 HPGD (0.48) HPGDRECQLEPHX1MAPTMEN1
SCHEMBL22731686 0.91 MEN1 (0.51) HPGDRECQLEPHX1MAPTMEN1
SCHEMBL25467053 0.91 MEN1 (0.51) HPGDRECQLEPHX1MAPTMEN1
SCHEMBL4147298 0.91 MEN1 (0.51) HPGDRECQLEPHX1MAPTMEN1
SCHEMBL4402979 0.90 HPGD (0.54) HPGDRECQLEPHX1MAPTALDH1A1
Hydrochloric Acid SCHEMBL27912903 0.89 HPGD (0.53) HPGDRECQLEPHX1MAPTALDH1A1
SCHEMBL6915624 0.86 NR1H2 (0.50) HPGDRECQLEPHX1MAPTMEN1
SCHEMBL35457 0.85 HPGD (0.49) HPGDRECQLEPHX1MAPTMEN1
SCHEMBL935410 0.85 HPGD (0.49) HPGDRECQLEPHX1MAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 148 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240246936-A1 SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-(PYRROLIDIN-3-YLVINYL)PYRIMIDINE OYSTER POINT PHARMA INC (US) 2024-07-25 US claimed
US-20230295126-A1 SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-PYRROLIDIN-3-YLVINYL)PYRIMIDINE TARGACEPT, INC. 2023-09-21 US claimed
US-11542253-B2 Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine Oyster Point Pharma, Inc. (US) 2023-01-03 US claimed
EP-3279195-A1 SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-(PYRROLIDIN-3-YLVINYL)PYRIMIDINE Oyster Point Pharma, Inc. (US) 2018-02-07 EP claimed
US-20160046609-A1 SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-PYRROLIDIN-3YLVINYL)PYRIMIDINE CATALYST BIOSCIENCES, INC. 2016-02-18 US claimed
EP-2358670-B1 A process for the preparation of tert-butyl (R)-3-vinylpyrrolidine-1-carboxylate and intermediates therefor TARGACEPT INC (US) 2012-10-24 EP claimed
US-8153821-B2 Compounds TARGACEPT, INC. (US) 2012-04-10 US claimed
US-20110269975-A1 NOVEL COMPOUNDS TARGACEPT, INC. (US) 2011-11-03 US claimed
US-20250313574-A1 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME EISAI R&D MANAGEMENT CO., LTD. (JP) 2025-10-09 US disclosed
EP-4536653-A2 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME Eisai R&D Management Co., Ltd. (JP) 2025-04-16 EP disclosed
US-20240246936-A1 SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-(PYRROLIDIN-3-YLVINYL)PYRIMIDINE OYSTER POINT PHARMA INC (US) 2024-07-25 US disclosed
US-11925651-B2 TEAD inhibitors and uses thereof Ikena Oncology, Inc. (US) 2024-03-12 US disclosed
WO-2023239906-A2 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME EISAI R&D MANAGEMENT CO., LTD. (JP) 2023-12-14 WO disclosed
WO-2023239906-A2 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME EISAI R&D MANAGEMENT CO., LTD. (JP) 2023-12-14 WO disclosed
US-20110021597-A1 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS THERAVANCE BIOPHARMA R&D IP, LLC 2011-01-27 US disclosed
WO-2010147938-A2 REVERSAL OF L-DOPA-INDUCED DYSKINESIA BY NEURONAL NICOTINIC RECEPTOR LIGANDS TARGACEPT, INC. (US) 2010-12-23 WO disclosed
WO-2010065449-A1 (R) -3- (E) -2- (PYRR0LIDIN-3-YL) VINYL) -5- (TETRAHYDR0PYRAN-4-YL0XY) PYRIDINE, ITS SALTS, ITS SYNTHESIS AND ITS USE AS LIGAND FOR NICOTINIC ACETYLCHOLINERGIC RECEPTORS TARGACEPT, INC. (US) 2010-06-10 WO disclosed
WO-2010065449-A1 (R) -3- (E) -2- (PYRR0LIDIN-3-YL) VINYL) -5- (TETRAHYDR0PYRAN-4-YL0XY) PYRIDINE, ITS SALTS, ITS SYNTHESIS AND ITS USE AS LIGAND FOR NICOTINIC ACETYLCHOLINERGIC RECEPTORS TARGACEPT, INC. (US) 2010-06-10 WO disclosed
WO-2010065447-A2 NOVEL COMPOUNDS TARGACEPT, INC. (US) 2010-06-10 WO disclosed
WO-2010065447-A2 NOVEL COMPOUNDS TARGACEPT, INC. (US) 2010-06-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110021597-A1 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS HTR6, SLC6A4, SLC6A2 HPGD 1449/4885RECQL 900/4885EPHX1 1172/4885
US-20240246936-A1 SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-(PYRROLIDIN-3-YLVINYL)PYRIMIDINE DPYD, NUDT5, DHPS HPGD 661/4885RECQL 991/4885EPHX1 959/4885
US-20110269975-A1 NOVEL COMPOUNDS CHRNB2, CHRNA2, CHRNA5 HPGD 2489/4885RECQL 3461/4885EPHX1 1094/4885
US-11925651-B2 TEAD inhibitors and uses thereof TEAD2, TEAD3, TEAD4 HPGD 223/4885RECQL 977/4885EPHX1 511/4885
US-20250313574-A1 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME NEU1, NEU2, NEU4 HPGD 1182/4885RECQL 4623/4885EPHX1 2703/4885
US-20160046609-A1 SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-PYRROLIDIN-3YLVINYL)PYRIMIDINE DPYD, DHPS, NUDT5 HPGD 735/4885RECQL 1304/4885EPHX1 1217/4885
US-20230295126-A1 SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-PYRROLIDIN-3-YLVINYL)PYRIMIDINE DPYD, DHPS, NUDT5 HPGD 739/4885RECQL 1157/4885EPHX1 1192/4885
US-11542253-B2 Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine DPYD, DHPS, NUDT5 HPGD 739/4885RECQL 1157/4885EPHX1 1192/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.