Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 7/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 7/20 | 0.39 |
| ▸ | GRIK5 | Q16478 | 7/20 | 0.39 |
| ▸ | GRIK3 | Q13003 | 6/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 5/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 5/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.39 |
| ▸ | GRIK4 | Q16099 | 4/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34461772 | 0.87 | CYP1A2 (0.35) | ALDH1A1FAAHMGLLMEN1KMT2A | |
| SCHEMBL34461790 | 0.86 | HCAR1 (0.33) | ALDH1A1FAAHMGLLKMT2AHCAR1 | |
| SCHEMBL34461723 | 0.83 | TRPA1 (0.42) | ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL34461760 | 0.83 | GRIA1 (0.32) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL34461744 | 0.82 | ALDH1A1 (0.37) | GRIK1GRIK2GRIK5GRIK3GRIA1 | |
| SCHEMBL34461739 | 0.70 | TRPA1 (0.43) | ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL34461734 | 0.69 | ALDH1A1 (0.36) | ALDH1A1FAAHMGLLKMT2AHCAR1 | |
| SCHEMBL34461733 | 0.69 | ADORA2A (0.38) | ALDH1A1HCAR1POLBMAPK1 | |
| SCHEMBL34461729 | 0.66 | ALDH1A1 (0.35) | ALDH1A1KMT2AMAPK1 | |
| SCHEMBL260928 | 0.64 | APEX1 (0.57) | GRIK1GRIK2GRIK5GRIK3GRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260098041-A1 | FUSED BICYCLIC PYRIMIDONES AS WRN INHIBITORS | INCYTE CORPORATION (US) | 2026-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260098041-A1 | FUSED BICYCLIC PYRIMIDONES AS WRN INHIBITORS | WRN, POLR1A, REV1 | GRIK1 2336/4885GRIK2 4306/4885GRIK5 4321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.