Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL133464 | 0.84 | ALDH1A1 (0.57) | CNR2L3MBTL1NR1H2ALDH1A1PKM | |
| SCHEMBL25736832 | 0.82 | L3MBTL1 (0.46) | CNR2L3MBTL1NR1H2ALDH1A1PKM | |
| SCHEMBL25168045 | 0.82 | L3MBTL1 (0.46) | CNR2L3MBTL1NR1H2ALDH1A1PKM | |
| SCHEMBL4698252 | 0.82 | SMN1; SMN2 (0.47) | CNR2L3MBTL1NR1H2ALDH1A1PKM | |
| SCHEMBL17329317 | 0.82 | NPC1 (0.56) | CNR2L3MBTL1NR1H2PKMKMT2A | |
| SCHEMBL14838247 | 0.81 | CYP1A2 (0.47) | CNR2L3MBTL1NR1H2ALDH1A1NR1H3 | |
| SCHEMBL2340371 | 0.81 | L3MBTL1 (0.45) | CNR2L3MBTL1NR1H2ALDH1A1PKM | |
| SCHEMBL2674793 | 0.80 | L3MBTL1 (0.47) | CNR2L3MBTL1NR1H2ALDH1A1PKM | |
| SCHEMBL14300652 | 0.80 | CYP1A2 (0.46) | CNR2L3MBTL1NR1H2ALDH1A1NR1H3 | |
| SCHEMBL133915 | 0.80 | CNR2 (0.51) | CNR2L3MBTL1NR1H2ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | CNR2 517/4885L3MBTL1 4616/4885NR1H2 844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.