Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | RXRG | P48443 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | WDR5 | P61964 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | OGG1 | O15527 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27348590 | 0.90 | FAAH (0.50) | KDM4EKMT2AALDH1A1FAAH | |
| SCHEMBL28654490 | 0.88 | KDM4E (0.43) | BCHERXRARXRBRXRGKDM4E | |
| SCHEMBL6691263 | 0.87 | BCHE (0.47) | BCHERXRARXRBRXRGKDM4E | |
| SCHEMBL27713200 | 0.87 | KDM4E (0.43) | BCHERXRARXRBRXRGKDM4E | |
| SCHEMBL11800597 | 0.85 | ALDH1A1 (0.44) | BCHERXRARXRBRXRGKDM4E | |
| SCHEMBL646091 | 0.85 | KMT2A (0.55) | RXRARXRBRXRGKMT2AALDH1A1 | |
| SCHEMBL103462 | 0.85 | BCHE (0.41) | BCHERXRARXRBRXRGKDM4E | |
| SCHEMBL19331388 | 0.85 | WDR5 (0.47) | BCHERXRARXRBRXRGKDM4E | |
| SCHEMBL11680457 | 0.85 | ACHE (0.61) | BCHERXRARXRBRXRGKDM4E | |
| SCHEMBL28755167 | 0.84 | KMT2A (0.43) | BCHERXRARXRBRXRGKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820692-B2 | Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2010-10-26 | — | — | US | disclosed |
| US-20090275607-A1 | Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2009-11-05 | — | — | US | disclosed |
| CN-100503571-C | Tetrahydro isoquinoline derivative and its preparation process and medicine use | UNIV CHINA PHARMA (CN) | 2009-06-24 | — | — | CN | disclosed |
| EP-2045243-A1 | TETRAHYDRO ISOQUINOLINE DERIVATIVES, PREPARATION METHODS AND MEDICINAL USES THEREOF | China Pharmaceutical University (CN) | 2009-04-08 | — | — | EP | disclosed |
| CN-1887872-A | Tetrahydro isoquinoline derivative and its prepn process and medicine use | UNIV CHINA PHARMACY (CN) | 2007-01-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275607-A1 | Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof | OPRK1, OPRD1, OPRL1 | BCHE 1556/4885RXRA 924/4885RXRB 1084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.