Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 12/20 | 0.41 |
| ▸ | CTSV | O60911 | 11/20 | 0.41 |
| ▸ | CTSS | P25774 | 11/20 | 0.41 |
| ▸ | CTSK | P43235 | 9/20 | 0.41 |
| ▸ | CTSB | P07858 | 6/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3451136 | 0.82 | TAAR1 (0.46) | CTSL | |
| SCHEMBL3451969 | 0.76 | LDHA (0.51) | — | |
| SCHEMBL1239155 | 0.76 | ACACB (0.38) | CTSK | |
| SCHEMBL1592472 | 0.72 | HCAR2 (0.68) | HCAR2NR4A2 | |
| SCHEMBL150216 | 0.70 | HCAR2 (0.50) | HCAR2 | |
| SCHEMBL29908312 | 0.70 | HCAR2 (0.50) | HCAR2 | |
| SCHEMBL11352257 | 0.69 | CTSL (0.48) | CTSLCTSVCTSSCTSKCTSB | |
| SCHEMBL1442961 | 0.69 | PNMT (0.56) | CTSLCTSVCTSSCTSKCTSB | |
| SCHEMBL8499045 | 0.68 | PNMT (0.55) | CTSLCTSVCTSSCTSKCTSB | |
| SCHEMBL27781513 | 0.68 | HCAR2 (0.48) | HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820692-B2 | Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2010-10-26 | — | — | US | disclosed |
| US-20090275607-A1 | Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2009-11-05 | — | — | US | disclosed |
| EP-2045243-A1 | TETRAHYDRO ISOQUINOLINE DERIVATIVES, PREPARATION METHODS AND MEDICINAL USES THEREOF | China Pharmaceutical University (CN) | 2009-04-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275607-A1 | Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof | OPRK1, OPRD1, OPRL1 | HCAR2 123/4885CTSL 3529/4885CTSV 3900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.