Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11441525 | 0.89 | SMN1; SMN2 (0.71) | POLBSMN1; SMN2 | |
| SCHEMBL31036181 | 0.87 | POLB (0.67) | POLB | |
| SCHEMBL3452625 | 0.81 | MEN1 (0.57) | SMN1; SMN2 | |
| SCHEMBL3845087 | 0.81 | ALDH1A1 (0.68) | POLBSMN1; SMN2 | |
| SCHEMBL27446239 | 0.80 | SMN1; SMN2 (0.81) | POLBSMN1; SMN2 | |
| SCHEMBL10422980 | 0.79 | POLB (0.74) | POLB | |
| SCHEMBL9632174 | 0.79 | POLB (0.57) | POLBSMN1; SMN2 | |
| SCHEMBL17916743 | 0.79 | RAB9A (0.69) | SMN1; SMN2 | |
| SCHEMBL12773610 | 0.79 | SMN1; SMN2 (0.75) | POLBSMN1; SMN2 | |
| SCHEMBL10933092 | 0.79 | TRPV1 (0.73) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820692-B2 | Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2010-10-26 | — | — | US | disclosed |
| US-20090275607-A1 | Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2009-11-05 | — | — | US | disclosed |
| EP-2045243-A1 | TETRAHYDRO ISOQUINOLINE DERIVATIVES, PREPARATION METHODS AND MEDICINAL USES THEREOF | China Pharmaceutical University (CN) | 2009-04-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275607-A1 | Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof | OPRK1, OPRD1, OPRL1 | POLB 2194/4885SMN1; SMN2 2941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.