Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CASP6 | P55212 | 2/20 | 0.33 |
| ▸ | APAF1 | O14727 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29844677 | 1.00 | MAOA (0.43) | MAOAMAOBHPGDRNASEH1CYP1A2 | |
| SCHEMBL7356037 | 0.77 | MAOA (0.43) | MAOAMAOBHPGDRNASEH1CYP1A2 | |
| SCHEMBL3239868 | 0.74 | HPGD (0.47) | MAOAMAOBHPGDRNASEH1CYP1A2 | |
| SCHEMBL29191977 | 0.73 | MAOA (0.39) | MAOAMAOBHPGDRNASEH1CYP1A2 | |
| SCHEMBL6527783 | 0.72 | CASP6 (0.50) | MAOAMAOBHPGDRNASEH1CYP1A2 | |
| SCHEMBL8088588 | 0.70 | ALDH1A1 (0.39) | MAOAMAOBHPGDRNASEH1CYP2A6 | |
| SCHEMBL7438103 | 0.69 | MEN1 (0.39) | MAOAMAOBHPGDRNASEH1GAA | |
| SCHEMBL8580844 | 0.68 | MAOB (0.39) | MAOAMAOBHPGDRNASEH1CYP2A6 | |
| SCHEMBL7334246 | 0.68 | CYP1A2 (0.45) | MAOAMAOBCYP1A2CYP2A6NOTUM | |
| SCHEMBL6645559 | 0.67 | MAOA (0.39) | MAOAMAOBHPGDGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776853-B2 | 2-amino-benzoxazinone derivatives for the treatment of obesity | NORGINE B.V. (NL) | 2010-08-17 | — | — | US | disclosed |
| EP-1631272-A4 | METHODS OF TREATING OBESITY AND RELATED DISORDERS USING TELLURIUM AND SELENIUM COMPOUNDS | RUBINSTEIN MENACHEM (IL) | 2009-01-07 | — | — | EP | disclosed |
| EP-1255742-B1 | 2-THIO-4H-3,1-BENZOXAZIN-4-ONE DERIVATIVES FOR USE AS ENZYME INHIBITORS | ALIZYME THERAPEUTICS LTD (GB) | 2008-12-17 | — | — | EP | disclosed |
| US-20060166957-A1 | Methods of treating obesity and related disorders using tellurium selenium compounds | BIOMAS LTD. (IL) | 2006-07-27 | — | — | US | disclosed |
| EP-1631272-A2 | METHODS OF TREATING OBESITY AND RELATED DISORDERS USING TELLURIUM AND SELENIUM COMPOUNDS | Rubinstein, Menachem (IL) | 2006-03-08 | — | — | EP | disclosed |
| US-6916808-B2 | 2-thio-4h-3, 1-benzoxazin-4-one derivatives for use as enzyme inhibitors | ALIZYME THERAPEUTICS LIMITED (GB) | 2005-07-12 | — | — | US | disclosed |
| US-20050032795-A1 | 2-Amino-benzoxazinones for the treatment of herpes simplex virus | G.D. SEARLE & CO. (US) | 2005-02-10 | — | — | US | disclosed |
| US-20050032793-A1 | 2-amino-benzoxazinones for the treatment of viral infections | G.D. SEARLE & CO. (US) | 2005-02-10 | — | — | US | disclosed |
| WO-2004110338-A2 | METHODS OF TREATING OBESITY AND RELATED DISORDERS USING TELLURIUM AND SELENIUM COMPOUNDS | BIOMAS LTD. (IL) | 2004-12-23 | — | — | WO | disclosed |
| US-6806269-B1 | EFFECTIVE AT LOWER CONCENTRATIONS; SUCH AS 6-(((1,1-DIMETHYL-ETHOXY)CARBONYL)AMINO)-5-METHYL-2-(METHYL(PHENYLMETHYL) -AMINO)-4H-3,1-BENZOXAZIN-4-ONE | G. D. SEARLE & COP | 2004-10-19 | — | — | US | disclosed |
| US-20030013707-A1 | 2-amino-benzoxazinone derivatives for the treatment of obesity | NORGINE B.V. (NL) | 2003-01-16 | — | — | US | disclosed |
| EP-1255742-A1 | 2-THIO-4H-3,1-BENZOXAZIN-4-ONE DERIVATIVES FOR USE AS ENZYME INHIBITORS | Alizyme Therapeutics Limited (GB) | 2002-11-13 | — | — | EP | disclosed |
| US-6380189-B1 | FOR TREATING HERPES-RELATED DISORDERS | G.D. SEARLE & CO. | 2002-04-30 | — | — | US | disclosed |
| EP-1122245-A3 | 2-Amino-benzoxazinones for the treatment of viral infections | G.D. Searle & Co. (US) | 2001-08-22 | — | — | EP | disclosed |
| EP-1122245-A2 | 2-Amino-benzoxazinones for the treatment of viral infections | G.D. Searle & Co. (US) | 2001-08-08 | — | — | EP | disclosed |
| WO-2001053278-A1 | 2-THIO-4H-3,1-BENZOXAZIN-4-ONE DERIVATIVES FOR USE AS ENZYME INHIBITORS | ALIZYME THERAPEUTICS LIMITED (GB) | 2001-07-26 | — | — | WO | disclosed |
| US-5985872-A | THERAPEUTIC TREATMENT OF HERPES VIRAL INFECTION | G.D. SEARLE & CO. (US) | 1999-11-16 | — | — | US | disclosed |
| WO-1998054192-A1 | THIENOXAZINONE DERIVATIVES AS ANTIVIRAL AGENTS | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-12-03 | — | — | WO | disclosed |
| WO-1998045298-A1 | ANTIVIRAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1998-10-15 | — | — | WO | disclosed |
| WO-1997048707-A1 | 4H-3,1-BENZOXAZIN-4-ONE DERIVATIVES AND ANALOGS AS ANTIVIRAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1997-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032793-A1 | 2-amino-benzoxazinones for the treatment of viral infections | IFNAR1, IL4I1, ACE2 | MAOA 4035/4885MAOB 2526/4885HPGD 3672/4885 |
| US-20060166957-A1 | Methods of treating obesity and related disorders using tellurium selenium compounds | SELENOI, AS3MT, SLC5A1 | MAOA 2678/4885MAOB 2719/4885HPGD 4787/4885 |
| US-20030013707-A1 | 2-amino-benzoxazinone derivatives for the treatment of obesity | CYP4X1, CYP2B6, BBOX1 | MAOA 160/4885MAOB 138/4885HPGD 1023/4885 |
| US-20050032795-A1 | 2-Amino-benzoxazinones for the treatment of herpes simplex virus | GABBR1, GABBR2, EBNA1BP2 | MAOA 1832/4885MAOB 888/4885HPGD 348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.