Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 1/20 | 0.41 |
| ▸ | DNM2 | P50570 | 3/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 7/20 | 0.39 |
| ▸ | MERTK | Q12866 | 7/20 | 0.39 |
| ▸ | GAS6 | Q14393 | 7/20 | 0.39 |
| ▸ | FLT3 | P36888 | 6/20 | 0.39 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21824036 | 0.85 | P2RX3 (0.44) | ULK1TYRO3MERTKGAS6FLT3 | |
| SCHEMBL2068179 | 0.83 | ULK1 (0.45) | ULK1LRRK2KMT2ACDK1CDK2 | |
| SCHEMBL15142272 | 0.82 | ULK1 (0.42) | ULK1TYRO3MERTKGAS6FLT3 | |
| SCHEMBL3378721 | 0.79 | KCNH3 (0.41) | DNM2TYRO3MERTKGAS6FLT3 | |
| SCHEMBL3457103 | 0.79 | KMT2A (0.44) | DNM2TYRO3MERTKGAS6FLT3 | |
| SCHEMBL15142751 | 0.74 | ULK1 (0.48) | ULK1LRRK2CDK1CDK2KDR | |
| SCHEMBL20836481 | 0.73 | ULK1 (0.47) | ULK1LRRK2KMT2ACDK1CDK2 | |
| SCHEMBL8489058 | 0.70 | DNM2 (0.42) | DNM2TYRO3MERTKGAS6FLT3 | |
| SCHEMBL16045208 | 0.70 | KDR (0.47) | ULK1KCNH3LRRK2KMT2ACDK1 | |
| SCHEMBL11173788 | 0.70 | KCNH3 (0.44) | DNM2KCNH3KMT2ANPSR1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | ULK1 2054/4885DNM2 2200/4885TYRO3 2798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.