SCHEMBL346041

SCHEMBL346041

CCC(NC(C)=O)S(=O)(=O)O

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.34
MAPT P10636 1/20 0.34
THRB P10828 1/20 0.34
ALOX15 P16050 1/20 0.34
NFKB1 P19838 1/20 0.34
PTGS2 P35354 1/20 0.34
THPO P40225 1/20 0.34
RECQL P46063 1/20 0.34
BLM P54132 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
ALDH1A1 P00352 2/20 0.33
TSHR P16473 1/20 0.32
PLA2G2C Q5R387 1/20 0.31
MAPK1 P28482 1/20 0.31
HIF1A Q16665 1/20 0.31
CA12 O43570 1/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
MMP1 P03956 1/20 0.30
MMP2 P08253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2513923 0.82 CYP2D6 (0.34) SMN1; SMN2ALDH1A1CA12CA1CA2
SCHEMBL3958639 0.80 KDM4E (0.33) KDM4EMAPTTHRBALOX15NFKB1
SCHEMBL17344111 0.80 CYP2C9 (0.43) KDM4EMAPTALDH1A1MAPK1CA12
SCHEMBL504372 0.80 PAOX (0.33) KDM4EMAPTTHRBALOX15NFKB1
SCHEMBL11255941 0.79 PLA2G2C (0.42) RECQLALDH1A1PLA2G2CMAPK1CA1
SCHEMBL182014 0.79 TGFBR1 (0.47)
SCHEMBL28901847 0.78 SMN1; SMN2 (0.36) KDM4EMAPTTHRBALOX15NFKB1
SCHEMBL29105385 0.78 KDM4E (0.32) KDM4EMAPTTHRBALOX15NFKB1
SCHEMBL7026251 0.78 CNR2 (0.34) ALDH1A1TSHRCA12CA1CA2
SCHEMBL347088 0.78 KDM4E (0.32) KDM4EMAPTTHRBALOX15NFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12201631-B2 Methods and compositions for reducing tactile dysfunction and anxiety associated with autism spectrum disorder, Rett syndrome, and fragile X syndrome PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2025-01-21 US claimed
US-20230031479-A1 METHODS AND COMPOSITIONS FOR REDUCING TACTILE DYSFUNCTION AND ANXIETY ASSOCIATED WITH AUTISM SPECTRUM DISORDER, RETT SYNDROME, AND FRAGILE X SYNDROME PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-02-02 US claimed
US-11547706-B2 Methods and compositions for reducing tactile dysfunction and anxiety associated with autism spectrum disorder, Rett syndrome, and Fragile X syndrome PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-01-10 US claimed
US-20200179374-A1 METHODS AND COMPOSITIONS FOR REDUCING TACTILE DYSFUNCTION AND ANXIETY ASSOCIATED WITH AUTISM SPECTRUM DISORDER, RETT SYNDROME, AND FRAGILE X SYNDROME PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2020-06-11 US claimed
EP-3468545-A1 METHODS AND COMPOSITIONS FOR REDUCING TACTILE DYSFUNCTION AND ANXIETY ASSOCIATED WITH AUTISM SPECTRUM DISORDER, RETT SYNDROME, AND FRAGILE X SYNDROME President and Fellows of Harvard College (US) 2019-04-17 EP claimed
US-9956189-B2 Material and methods for treating developmental disorders including comorbid and idiopathic autism INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2018-05-01 US claimed
WO-2017214442-A1 METHODS AND COMPOSITIONS FOR REDUCING TACTILE DYSFUNCTION AND ANXIETY ASSOCIATED WITH AUTISM SPECTRUM DISORDER, RETT SYNDROME, AND FRAGILE X SYNDROME PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2017-12-14 WO claimed
US-20160303057-A1 MATERIAL AND METHODS FOR TREATING DEVELOPMENTAL DISORDERS INCLUDING COMORBID AND IDIOPATHIC AUTISM INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2016-10-20 US claimed
US-9463172-B2 Material and methods for treating developmental disorders including comorbid and idiopathic autism INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) 2016-10-11 US claimed
EP-2395990-B1 Material and methods for treating developmental disorders including comorbid and idiopathic autism UNIV INDIANA RES & TECH CORP (US) 2015-01-07 EP claimed
US-20120016036-A1 MATERIAL AND METHODS FOR TREATING DEVELOPMENTAL DISORDERS INCLUDING COMORBID AND IDIOPATHIC AUTISM INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) 2012-01-19 US claimed
WO-2010093859-A1 MATERIAL AND METHODS FOR TREATING DEVELOPMENTAL DISORDERS INCLUDING COMORBID AND IDIOPATHIC AUTISM INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) 2010-08-19 WO claimed
US-20250186429-A1 METHODS AND COMPOSITIONS FOR REDUCING TACTILE DYSFUNCTION AND ANXIETY ASSOCIATED WITH AUTISM SPECTRUM DISORDER, RETT SYNDROME, AND FRAGILE X SYNDROME PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2025-06-12 US disclosed
US-12201631-B2 Methods and compositions for reducing tactile dysfunction and anxiety associated with autism spectrum disorder, Rett syndrome, and fragile X syndrome PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2025-01-21 US disclosed
US-12042566-B2 Formulations of homotaurines and salts thereof CONFLUENCE PHARMACEUTICALS, LLC (US) 2024-07-23 US disclosed
US-20230233516-A1 HIGH PENETRATION COMPOSITIONS AND THEIR APPLICATIONS TECHFIELDS PHARMA CO., LTD (CN) 2023-07-27 US disclosed
US-20020119912-A1 Treatment of posttraumatic strees disorder, obsessive-compulsive disorder and related neuropsychiatric disorders SYNCHRONEURON INC. 2002-08-29 US disclosed
US-6391922-B1 ADMINISTERING NEUROTRANSMITTER SYNCHRONEURON, LLC 2002-05-21 US disclosed
EP-1162960-A2 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF POSTTRAUMATIC STRESS DISORDER Synchroneuron, LLC (US) 2001-12-19 EP disclosed
WO-2000056301-A2 TREATMENT OF POSTTRAUMATIC STRESS DISORDER, OBSESSIVE-COMPULSIVE DISORDER AND RELATED NEUROPSYCHIATRIC DISORDERS SYNCHRONEURON, LLC (US) 2000-09-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250186429-A1 METHODS AND COMPOSITIONS FOR REDUCING TACTILE DYSFUNCTION AND ANXIETY ASSOCIATED WITH AUTISM SPECTRUM DISORDER, RETT SYNDROME, AND FRAGILE X SYNDROME MECP2, GABBR1, GABBR2 KDM4E 4124/4885MAPT 613/4885THRB 290/4885
US-20120016036-A1 MATERIAL AND METHODS FOR TREATING DEVELOPMENTAL DISORDERS INCLUDING COMORBID AND IDIOPATHIC AUTISM GRIN3A, GRIK3, INA KDM4E 3216/4885MAPT 624/4885THRB 3807/4885
US-11547706-B2 Methods and compositions for reducing tactile dysfunction and anxiety associated with autism spectrum disorder, Rett syndrome, and Fragile X syndrome MECP2, GABBR1, GABBR2 KDM4E 4124/4885MAPT 613/4885THRB 290/4885
US-12201631-B2 Methods and compositions for reducing tactile dysfunction and anxiety associated with autism spectrum disorder, Rett syndrome, and fragile X syndrome MECP2, GABBR1, GABBR2 KDM4E 4124/4885MAPT 613/4885THRB 290/4885
US-20160303057-A1 MATERIAL AND METHODS FOR TREATING DEVELOPMENTAL DISORDERS INCLUDING COMORBID AND IDIOPATHIC AUTISM GRIN3A, GRIK3, INA KDM4E 3216/4885MAPT 624/4885THRB 3807/4885
US-20200179374-A1 METHODS AND COMPOSITIONS FOR REDUCING TACTILE DYSFUNCTION AND ANXIETY ASSOCIATED WITH AUTISM SPECTRUM DISORDER, RETT SYNDROME, AND FRAGILE X SYNDROME MECP2, GABBR1, GABBR2 KDM4E 4124/4885MAPT 613/4885THRB 290/4885
US-20230031479-A1 METHODS AND COMPOSITIONS FOR REDUCING TACTILE DYSFUNCTION AND ANXIETY ASSOCIATED WITH AUTISM SPECTRUM DISORDER, RETT SYNDROME, AND FRAGILE X SYNDROME MECP2, GABBR1, GABBR2 KDM4E 4124/4885MAPT 613/4885THRB 290/4885
US-20230233516-A1 HIGH PENETRATION COMPOSITIONS AND THEIR APPLICATIONS SLC5A7, SLC19A1, SLC43A1 KDM4E 2401/4885MAPT 2642/4885THRB 3974/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.