Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25590205 | 1.00 | LMNA (0.36) | LMNACYP2C19HIF1ADRD3SLC6A3 | |
| SCHEMBL26198162 | 1.00 | LMNA (0.36) | LMNACYP2C19HIF1ADRD3SLC6A3 | |
| SCHEMBL2745754 | 0.83 | CA2 (0.35) | LMNACYP2C19HIF1ADRD3SLC6A3 | |
| SCHEMBL25587280 | 0.83 | POLB (0.33) | LMNAALDH1A1POLBHDAC6KDM4E | |
| SCHEMBL25587279 | 0.83 | POLB (0.33) | LMNAALDH1A1POLBHDAC6KDM4E | |
| SCHEMBL25587275 | 0.83 | POLB (0.33) | LMNAALDH1A1POLBHDAC6KDM4E | |
| SCHEMBL26023515 | 0.82 | RIPK1 (0.42) | LMNACYP2C19HIF1ADRD3SLC6A3 | |
| SCHEMBL20692421 | 0.80 | LMNA (0.33) | LMNACYP2C19HIF1AEGFRSRC | |
| SCHEMBL3139336 | 0.78 | ALDH1A1 (0.46) | LMNACYP2C19HIF1AALDH1A1EGFR | |
| SCHEMBL27081436 | 0.78 | ALDH1A1 (0.46) | LMNACYP2C19HIF1AALDH1A1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-09-07 | — | — | US | disclosed |
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-09-07 | — | — | US | disclosed |
| US-20230174538-A1 | Tricyclic heterocycles | MERCK PATENT GMBH (DE) | 2023-06-08 | — | — | US | disclosed |
| US-20220089593-A1 | PDE9 INHIBITOR AND USE THEREOF | TRANSTHERA SCIENCES (NANJING), INC. (CN) | 2022-03-24 | — | — | US | disclosed |
| US-20210188775-A1 | CARBOXAMIDE AND SULFONAMIDE DERIVATIVES USEFUL AS TEAD MODULATORS | GENENTECH, INC. (US) | 2021-06-24 | — | — | US | disclosed |
| EP-2248820-B1 | Universal supports for oligonucleotide synthesis | GLEN RES CORP (US) | 2014-01-08 | — | — | EP | disclosed |
| EP-1404695-B1 | UNIVERSAL SUPPORTS FOR OLIGONUCLEOTIDE SYNTHESIS | GLEN RES CORP (US) | 2013-04-10 | — | — | EP | disclosed |
| US-8178681-B2 | methyl 3-methyl-2-{[2-oxo-1-(2-oxo-ethyl)-1,2,5,6,7,8,9,10-octahydro-cycloocta[b]pyridine-3-carbonyl]-amino}-butyrate; cannabinoid receptor agonist; antiinflammatory agent, immunostimulant, analgesic; atopic dermatitis; excellent in photostability, and have excellent transdermal and oral absorbency | SHIONOGI & CO., LTD. (JP) | 2012-05-15 | — | — | US | disclosed |
| EP-2248820-A1 | Universal supports for oligonucleotide synthesis | Glen Research Corporation (US) | 2010-11-10 | — | — | EP | disclosed |
| US-7491817-B2 | Universal supports for oligonucleotide synthesis | GLEN RESEARCH CORPORATION (US) | 2009-02-17 | — | — | US | disclosed |
| US-20080103139-A1 | 3-Carbamoyl-2-Pyridone Derivative | SHIONOGI & CO. LTD. (JP) | 2008-05-01 | — | — | US | disclosed |
| US-20050250116-A1 | Universal supports for oligonucleotide synthesis | GLEN RESEARCH CORPORATION (US) | 2005-11-10 | — | — | US | disclosed |
| US-6770754-B2 | FUNCTIONALIZED POLYMERIC OR SILICA BASE MATERIAL; DO NOT INCLUDE A PRE-ATTACHED NUCLEOSIDE, AND THEREFORE CAN BE USED UNIVERSALLY FOR ANY NA OR RNA SYNTHESIS; FAST CLEAVAGE AND DEPHOSPHORYLATION AT RELATIVELY LOW TEMPERATURES | GLEN RESEARCH COPORATION | 2004-08-03 | — | — | US | disclosed |
| EP-1404695-A2 | UNIVERSAL SUPPORTS FOR OLIGONUCLEOTIDE SYNTHESIS | Glen Research Corporation (US) | 2004-04-07 | — | — | EP | disclosed |
| US-20020137855-A1 | Universal supports for oligonucleotide synthesis | GLEN RESEARCH CORPORATION (US) | 2002-09-26 | — | — | US | disclosed |
| WO-2002044398-A2 | UNIVERSAL SUPPORTS FOR OLIGONUCLEOTIDE SYNTHESIS | GLEN RESEARCH CORPORATION (US) | 2002-06-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250116-A1 | Universal supports for oligonucleotide synthesis | FBL, NSUN2, NOP2 | LMNA 1402/4885CYP2C19 3748/4885HIF1A 2627/4885 |
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | YAP1, TERF2IP, TEAD1 | LMNA 1845/4885CYP2C19 4791/4885HIF1A 1972/4885 |
| US-20080103139-A1 | 3-Carbamoyl-2-Pyridone Derivative | CNR1, CNR2, HRH4 | LMNA 3604/4885CYP2C19 1098/4885HIF1A 3381/4885 |
| US-20020137855-A1 | Universal supports for oligonucleotide synthesis | FBL, NSUN2, NOP2 | LMNA 1368/4885CYP2C19 3800/4885HIF1A 2298/4885 |
| US-20220089593-A1 | PDE9 INHIBITOR AND USE THEREOF | PDE9A, PDE12, PDE5A | LMNA 1702/4885CYP2C19 57/4885HIF1A 1811/4885 |
| US-20230174538-A1 | Tricyclic heterocycles | YAP1, TEAD1, TERF2IP | LMNA 2014/4885CYP2C19 4683/4885HIF1A 1789/4885 |
| US-20210188775-A1 | CARBOXAMIDE AND SULFONAMIDE DERIVATIVES USEFUL AS TEAD MODULATORS | TEAD2, TEAD1, SULT2A1 | LMNA 4567/4885CYP2C19 336/4885HIF1A 484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.