Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 3/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467313 | 0.88 | KATNA1 (0.35) | HPGDCTSAPRKDCKDM1AKDM4E | |
| SCHEMBL3467338 | 0.88 | CTSA (0.38) | SYKCASP1PARP1CTSASMN1; SMN2 | |
| SCHEMBL3467721 | 0.82 | CASP1 (0.49) | HPGDJAK2CASP1PARP1PARP2 | |
| SCHEMBL2117509 | 0.78 | ACLY (0.42) | KDM4EALDH1A1PIK3CA | |
| SCHEMBL3467342 | 0.72 | ACLY (0.45) | CTSA | |
| SCHEMBL3466788 | 0.70 | CASP1 (0.50) | SYKCASP1PARP1P2RX7KDM1A | |
| SCHEMBL3466612 | 0.68 | CA2 (0.36) | SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL3342952 | 0.67 | P2RX7 (0.46) | SYKJAK2PARP1P2RX7KDM1A | |
| SCHEMBL3713934 | 0.67 | PARP1 (0.50) | CASP1PARP1PARP2 | |
| SCHEMBL3467724 | 0.65 | CYP11B1 (0.47) | HPGDSMN1; SMN2KDM1AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010076034-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-07-08 | — | — | WO | disclosed |