Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 2/20 | 0.53 |
| ▸ | MMP13 | P45452 | 2/20 | 0.53 |
| ▸ | MME | P08473 | 2/20 | 0.46 |
| ▸ | CTSC | P53634 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467200 | 0.87 | MMP12 (0.60) | MMP12MMP13MMECTSCADAMTS4 | |
| SCHEMBL3466565 | 0.85 | GPR34 (0.54) | MMP12MMP13ADAMTS4FFAR1FFAR4 | |
| SCHEMBL3467017 | 0.82 | MMP12 (0.57) | MMP12MMP13MMEADAMTS4MCHR1 | |
| SCHEMBL7924636 | 0.80 | MMP12 (0.65) | MMP12MMP13MMECTSCADAMTS4 | |
| SCHEMBL3467000 | 0.77 | MMP12 (0.51) | MMP12MMP13ADAMTS4FFAR1FFAR4 | |
| SCHEMBL3467425 | 0.76 | MMP12 (0.54) | MMP12MMP13MMECTSCADAMTS4 | |
| SCHEMBL3466777 | 0.76 | MMP12 (0.54) | MMP12MMP13MMECTSCADAMTS4 | |
| SCHEMBL3466325 | 0.75 | FFAR1 (0.57) | MMP12MMP13ADAMTS4FFAR1FFAR4 | |
| SCHEMBL12646553 | 0.74 | MMP12 (0.56) | MMP12MMP13MMEHDAC1ADAMTS4 | |
| SCHEMBL7928277 | 0.73 | MMP12 (0.64) | MMP12MMP13MMEADAMTS4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010070076-A1 | ALKANOIC ACID DERIVATIVES AND THEIR THERAPEUTIC USE AS HDAC INHIBITORS | CRYSTAX PHARMACEUTICALS, S.L. (ES) | 2010-06-24 | — | — | WO | claimed |
| WO-2010070076-A1 | ALKANOIC ACID DERIVATIVES AND THEIR THERAPEUTIC USE AS HDAC INHIBITORS | CRYSTAX PHARMACEUTICALS, S.L. (ES) | 2010-06-24 | — | — | WO | disclosed |