Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | PELP1 | Q8IZL8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19035895 | 0.92 | TDP1 (0.44) | HTTPOLBALDH1A1TDP1MAPT | |
| SCHEMBL3471735 | 0.91 | HTT (0.50) | HTTPOLBALDH1A1TDP1MAPT | |
| SCHEMBL1012443 | 0.87 | POLB (0.56) | HTTPOLBALDH1A1MAPTNPC1 | |
| SCHEMBL1012859 | 0.87 | POLB (0.56) | HTTPOLBALDH1A1MAPTNPC1 | |
| SCHEMBL9865038 | 0.84 | NPC1 (0.45) | HTTALDH1A1MAPTNPC1KDM4E | |
| SCHEMBL1013315 | 0.83 | POLB (0.50) | HTTPOLBALDH1A1TDP1MAPT | |
| SCHEMBL6661001 | 0.81 | ALDH1A1 (0.48) | HTTALDH1A1TDP1MAPTNPC1 | |
| SCHEMBL264575 | 0.79 | ALDH1A1 (0.48) | HTTPOLBALDH1A1MAPTNPC1 | |
| SCHEMBL14705129 | 0.78 | HTT (0.55) | HTTPOLBALDH1A1MAPTNPC1 | |
| SCHEMBL28708249 | 0.78 | POLB (0.46) | HTTPOLBALDH1A1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102746242-A | Synthesis method of 6, 7-substituent-4-aniline quinazoline | OMEGA CO LTD | 2012-10-24 | — | — | CN | disclosed |
| CN-101863844-B | Synthesis method of 6, 7-substituent-4-aniline quinazoline | XIANGZHEN BIOLOGY TECHNOLOGY CO LTD | 2012-10-03 | — | — | CN | disclosed |
| WO-2011147102-A1 | SYNTHETIC METHOD FOR 6,7-SUBSTITUENTS-4-ANILINE QUINAZOLINE | 翔真生物科技股份有限公司 (CN) | 2011-12-01 | — | — | WO | disclosed |
| US-20100267949-A1 | Method of Synthesizing 6,7-Substituted 4-Anilino Quinazoline | OMEGA MEDICAL TAIWAN LIMITED (TW) | 2010-10-21 | — | — | US | disclosed |
| CN-101863844-A | Synthesis method of 6, 7-substituent-4-aniline quinazoline | XIANGZHEN BIOLOGY TECHNOLOGY CO LTD | 2010-10-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267949-A1 | Method of Synthesizing 6,7-Substituted 4-Anilino Quinazoline | NQO2, ATIC, CYP3A7 | HTT 1332/4885POLB 2315/4885ALDH1A1 878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.