Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 8/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13731787 | 1.00 | ITGA4 (0.40) | ITGA4ITGB7P2RY12MAPTTDP1 | |
| SCHEMBL3470853 | 1.00 | ITGA4 (0.40) | ITGA4ITGB7P2RY12MAPTTDP1 | |
| SCHEMBL28287518 | 0.94 | KLK5 (0.39) | ITGA4ITGB7P2RY12PPARGPPARA | |
| SCHEMBL17929798 | 0.91 | ADAMTS4 (0.44) | ITGA4ITGB7MAPTTDP1AAK1 | |
| SCHEMBL16538739 | 0.91 | ADAMTS4 (0.44) | ITGA4ITGB7MAPTTDP1AAK1 | |
| SCHEMBL30455955 | 0.91 | PPARA (0.43) | P2RY12MMP9PPARGPPARAPPARD | |
| SCHEMBL17929800 | 0.84 | PSMB8 (0.39) | ITGA4ITGB7P2RY12MAPTTDP1 | |
| SCHEMBL30277500 | 0.84 | PSMB8 (0.39) | ITGA4ITGB7P2RY12MAPTTDP1 | |
| SCHEMBL6740472 | 0.83 | ITGA4 (0.43) | ITGA4ITGB7MAPTTDP1AAK1 | |
| SCHEMBL6740469 | 0.83 | ITGA4 (0.43) | ITGA4ITGB7MAPTTDP1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086924-B1 | [F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION | PIRAMAL IMAGING SA (CH) | 2018-09-12 | — | — | EP | disclosed |
| US-9464087-B2 | Difluoromethylation of unsaturated compounds | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-10-11 | — | — | US | disclosed |
| EP-2785723-B1 | DIFLUOROMETHYLATION OF UNSATURATED COMPOUNDS | SCRIPPS RESEARCH INST (US) | 2016-10-05 | — | — | EP | disclosed |
| EP-2705011-B1 | NOVEL PRECURSORS OF GLUTAMATE DERIVATIVES | PIRAMAL IMAGING SA (CH) | 2016-08-17 | — | — | EP | disclosed |
| EP-2705011-B1 | NOVEL PRECURSORS OF GLUTAMATE DERIVATIVES | PIRAMAL IMAGING SA (CH) | 2016-08-17 | — | — | EP | disclosed |
| US-9375497-B2 | [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamine, derivatives thereof and use thereof and processes for their preparation | PIRAMAL IMAGING SA (CH) | 2016-06-28 | — | — | US | disclosed |
| US-9238631-B2 | Radiolabeled amino acids for diagnostic imaging | PIRAMAL IMAGING SA (CH) | 2016-01-19 | — | — | US | disclosed |
| US-9000037-B2 | Precursors of glutamate derivatives | PIRAMAL IMAGING SA (CH) | 2015-04-07 | — | — | US | disclosed |
| US-9000037-B2 | Precursors of glutamate derivatives | PIRAMAL IMAGING SA (CH) | 2015-04-07 | — | — | US | disclosed |
| US-20150011773-A1 | RADIOLABELED AMINO ACIDS FOR DIAGNOSTIC IMAGING | PIRAMAL IMAGING SA (CH) | 2015-01-08 | — | — | US | disclosed |
| US-20150011760-A1 | Difluoromethylation Of Unsaturated Compounds | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-01-08 | — | — | US | disclosed |
| US-20140301948-A1 | [F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2014-10-09 | — | — | US | disclosed |
| US-20140243532-A1 | NOVEL PRECURSORS OF GLUTAMATE DERIVATIVES | PIRAMAL IMAGING SA (CH) | 2014-08-28 | — | — | US | disclosed |
| US-20140243532-A1 | NOVEL PRECURSORS OF GLUTAMATE DERIVATIVES | PIRAMAL IMAGING SA (CH) | 2014-08-28 | — | — | US | disclosed |
| EP-2705012-A1 | RADIOLABELED AMINO ACIDS FOR DIAGNOSTIC IMAGING | Piramal Imaging SA (CH) | 2014-03-12 | — | — | EP | disclosed |
| WO-2012150220-A1 | RADIOLABELED AMINO ACIDS FOR DIAGNOSTIC IMAGING | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-11-08 | — | — | WO | disclosed |
| US-20100217011-A1 | [F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-08-26 | — | — | US | disclosed |
| EP-2086924-A1 | [F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-08-12 | — | — | EP | disclosed |
| EP-1923382-A1 | [18F] labelled L-glutamic acid, [18F] labelled glutamine, their derivatives, their use and processes for their preparation | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-05-21 | — | — | EP | disclosed |
| WO-2008052788-A1 | [F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100217011-A1 | [F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION | GLUL, GFPT1, QPCT | ITGA4 4008/4885ITGB7 2931/4885P2RY12 2736/4885 |
| US-20150011773-A1 | RADIOLABELED AMINO ACIDS FOR DIAGNOSTIC IMAGING | SLC1A5, SLC6A19, BCAT2 | ITGA4 3564/4885ITGB7 2496/4885P2RY12 2817/4885 |
| US-20140301948-A1 | [F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION | GLUL, GFPT1, QPCT | ITGA4 4008/4885ITGB7 2931/4885P2RY12 2736/4885 |
| US-20140243532-A1 | NOVEL PRECURSORS OF GLUTAMATE DERIVATIVES | GLUL, GRIN1, SLC7A11 | ITGA4 4392/4885ITGB7 4319/4885P2RY12 2858/4885 |
| US-20150011760-A1 | Difluoromethylation Of Unsaturated Compounds | ZRANB2, FDPS, NISCH | ITGA4 3483/4885ITGB7 2510/4885P2RY12 4562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.