Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | CASP1 | P29466 | 1/20 | 1.00 |
| ▸ | CASP7 | P55210 | 1/20 | 1.00 |
| ▸ | NCF1 | P14598 | 4/20 | 0.53 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | GNG2 | P59768 | 1/20 | 0.49 |
| ▸ | GNB1 | P62873 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TERT | O14746 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL439655 | 0.89 | ALDH1A1 (0.80) | ALDH1A1HSD17B10CASP1CASP7NCF1 | |
| SCHEMBL437286 | 0.83 | HSD17B10 (0.71) | ALDH1A1HSD17B10CASP1CASP7NCF1 | |
| SCHEMBL4748820 | 0.79 | ALDH1A1 (0.66) | ALDH1A1HSD17B10CASP1CASP7NCF1 | |
| SCHEMBL27906713 | 0.79 | ALDH1A1 (0.65) | ALDH1A1HSD17B10CASP1CASP7NCF1 | |
| SCHEMBL439264 | 0.78 | HSD17B10 (0.64) | ALDH1A1HSD17B10CASP1CASP7NCF1 | |
| SCHEMBL27890180 | 0.77 | ALDH1A1 (0.62) | ALDH1A1HSD17B10CASP1CASP7NCF1 | |
| SCHEMBL438604 | 0.75 | NCF1 (0.63) | ALDH1A1HSD17B10CASP1CASP7NCF1 | |
| SCHEMBL3235863 | 0.75 | NCF1 (0.63) | ALDH1A1HSD17B10CASP1CASP7NCF1 | |
| Hydrochloric Acid SCHEMBL30579056 | 0.74 | NCF1 (0.61) | ALDH1A1HSD17B10CASP1CASP7NCF1 | |
| SCHEMBL439542 | 0.73 | ALDH1A1 (0.58) | ALDH1A1HSD17B10CASP1CASP7NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9211296-B2 | Therapeutic compounds for blocking DNA synthesis of POX viruses | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-12-15 | — | — | US | disclosed |
| US-9211296-B2 | Therapeutic compounds for blocking DNA synthesis of POX viruses | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-12-15 | — | — | US | disclosed |
| US-9211296-B2 | Therapeutic compounds for blocking DNA synthesis of POX viruses | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-12-15 | — | — | US | disclosed |
| US-20130338117-A1 | THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-12-19 | — | — | US | disclosed |
| US-8524719-B2 | Therapeutic compounds for blocking DNA synthesis of pox viruses | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-09-03 | — | — | US | disclosed |
| US-8524719-B2 | Therapeutic compounds for blocking DNA synthesis of pox viruses | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-09-03 | — | — | US | disclosed |
| US-8524719-B2 | Therapeutic compounds for blocking DNA synthesis of pox viruses | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-09-03 | — | — | US | disclosed |
| US-20120322770-A1 | THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-12-20 | — | — | US | disclosed |
| US-20120322770-A1 | THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-12-20 | — | — | US | disclosed |
| US-20120322770-A1 | THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-12-20 | — | — | US | disclosed |
| US-8278342-B2 | Therapeutic compounds for blocking DNA synthesis of pox viruses | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-10-02 | — | — | US | disclosed |
| US-8278342-B2 | Therapeutic compounds for blocking DNA synthesis of pox viruses | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-10-02 | — | — | US | disclosed |
| US-8278342-B2 | Therapeutic compounds for blocking DNA synthesis of pox viruses | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-10-02 | — | — | US | disclosed |
| US-20100035887-A1 | THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-11 | — | — | US | disclosed |
| US-20100035887-A1 | THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-11 | — | — | US | disclosed |
| US-20100035887-A1 | THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-11 | — | — | US | disclosed |
| WO-2009008906-A2 | THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2009-01-15 | — | — | WO | disclosed |
| US-20080020973-A1 | Assays for identification of topoisomerase inhibitors | THE JOHNS HOPKINS UNIVERSITY (US) | 2008-01-24 | — | — | US | disclosed |
| US-20080020973-A1 | Assays for identification of topoisomerase inhibitors | THE JOHNS HOPKINS UNIVERSITY (US) | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322770-A1 | THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES | TPX2, POLB, POLM | ALDH1A1 4558/4885HSD17B10 3605/4885CASP1 2297/4885 |
| US-20080020973-A1 | Assays for identification of topoisomerase inhibitors | TOP1, TOP2A, TOP2B | ALDH1A1 3092/4885HSD17B10 810/4885CASP1 2507/4885 |
| US-20100035887-A1 | THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES | TPX2, POLB, POLM | ALDH1A1 4558/4885HSD17B10 3605/4885CASP1 2297/4885 |
| US-20130338117-A1 | THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES | TPX2, POLB, POLM | ALDH1A1 4558/4885HSD17B10 3605/4885CASP1 2297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.