Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 3/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.31 |
| ▸ | USP19 | O94966 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3493147 | 1.00 | SMN1; SMN2 (0.34) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL13341040 | 0.94 | GPR119 (0.36) | MAPTTP53GPR119 | |
| SCHEMBL13341044 | 0.94 | GPR119 (0.36) | MAPTTP53GPR119 | |
| SCHEMBL3492458 | 0.90 | LMNA (0.36) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL13341038 | 0.89 | LMNA (0.36) | MAPTNPC1LMNATP53GPR119 | |
| SCHEMBL3494977 | 0.89 | GPR119 (0.37) | MAPTTP53GPR119USP19 | |
| SCHEMBL3493445 | 0.87 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL13341048 | 0.87 | SMN1; SMN2 (0.37) | SMN1; SMN2MAPTTP53GPR119NR1H3 | |
| SCHEMBL3492878 | 0.85 | ALDH1A1 (0.37) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL13341063 | 0.85 | CTSS (0.37) | MAPTGPR119NR1H3NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100121048-A1 | Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100121048-A1 | Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension | REN, AGTR1, AGTR2 | SMN1; SMN2 4730/4885MAPT 4821/4885NPC1 3189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.