Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | FCER2 | P06734 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 2/20 | 0.40 |
| ▸ | METAP1 | P53582 | 2/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27782445 | 0.80 | ALDH1A1 (0.49) | HPGDEPHX1RAB9ANPC1ALDH1A1 | |
| SCHEMBL2008481 | 0.78 | ALDH1A1 (0.51) | EPHX1ALDH1A1KMT2AGAA | |
| SCHEMBL29214291 | 0.76 | METAP2 (0.46) | HPGDRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29214293 | 0.76 | METAP2 (0.46) | HPGDRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL28784000 | 0.75 | NPC1 (0.51) | HPGDEPHX1RAB9ANPC1ALDH1A1 | |
| SCHEMBL28020511 | 0.73 | SCN9A (0.43) | RAB9AALDH1A1SMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL842299 | 0.73 | TP53 (0.44) | ALDH1A1SMN1; SMN2METAP2METAP1CCR1 | |
| SCHEMBL19975381 | 0.70 | SMN1; SMN2 (0.51) | HPGDEPHX1RAB9ANPC1ALDH1A1 | |
| SCHEMBL4098800 | 0.69 | CPB2 (0.41) | HPGDEPHX1KMT2AMETAP2METAP1 | |
| SCHEMBL19974930 | 0.69 | LTA4H (0.50) | HPGDEPHX1RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575208-B2 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-11-05 | — | — | US | disclosed |
| US-20100272681-A1 | Inhibitors of Serine Proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100272681-A1 | Inhibitors of Serine Proteases | SERPINB1, PRSS1, SPINT2 | HPGD 1247/4885EPHX1 924/4885RAB9A 3172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.