Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3514649 | 1.00 | TDP1 (0.60) | TDP1CYP2C19KDM4EMEN1KMT2A | |
| SCHEMBL5676812 | 0.88 | TDP1 (0.48) | TDP1CYP2C19KDM4EMEN1KMT2A | |
| SCHEMBL5676823 | 0.88 | TDP1 (0.48) | TDP1CYP2C19KDM4EMEN1KMT2A | |
| SCHEMBL5676816 | 0.88 | TDP1 (0.48) | TDP1CYP2C19KDM4EMEN1KMT2A | |
| SCHEMBL6977513 | 0.77 | TDP1 (0.62) | TDP1CYP2C19KDM4EMEN1KMT2A | |
| SCHEMBL678566 | 0.77 | TDP1 (0.62) | TDP1CYP2C19KDM4EMEN1KMT2A | |
| SCHEMBL13221154 | 0.77 | TDP1 (0.62) | TDP1CYP2C19KDM4EKMT2ALMNA | |
| SCHEMBL19182708 | 0.75 | TDP1 (1.00) | TDP1CYP2C19KDM4EKMT2ALMNA | |
| SCHEMBL19183375 | 0.75 | TDP1 (1.00) | TDP1CYP2C19KDM4EKMT2ALMNA | |
| SCHEMBL20721986 | 0.71 | TDP1 (0.56) | TDP1CYP2C19KDM4EKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4720055-A1 | CBL-B INHIBITORS AND METHODS OF USE THEREOF | Arcus Biosciences, Inc. (US) | 2026-04-08 | — | — | EP | disclosed |
| US-20250011318-A1 | CBL-B INHIBITORS AND METHODS OF USE THEREOF | ARCUS BIOSCIENCES, INC. (US) | 2025-01-09 | — | — | US | disclosed |
| WO-2024243502-A1 | CBL-B INHIBITORS AND METHODS OF USE THEREOF | ARCUS BIOSCIENCES, INC. (US) | 2024-11-28 | — | — | WO | disclosed |
| US-20230242532-A1 | TETRACYCLIC PYRIMIDINONE COMPOUND, PREPARATION METHOD THEREFOR, AND COMPOSITION AND USE THEREOF | NEUSCO BIOTECH LIMITED (CN) | 2023-08-03 | — | — | US | disclosed |
| EP-4039687-A1 | TETRACYCLIC PYRIMIDINONE COMPOUND, PREPARATION METHOD THEREFOR, AND COMPOSITION AND USE THEREOF | Neusco Biotech Limited (CN) | 2022-08-10 | — | — | EP | disclosed |
| US-20210040043-A1 | HALOGEN SUBSTITUTED DIKETONES, PYRAZOLE COMPOUNDS AND PROCESSES FOR THE MANUFACTURE OF PYRAZOLE COMPOUNDS | SOLVAY (BE) | 2021-02-11 | — | — | US | disclosed |
| US-10829456-B2 | Halogen substituted diketones, pyrazole compounds and processes for the manufacture of pyrazole compounds | SOLVAY SA (BE) | 2020-11-10 | — | — | US | disclosed |
| EP-3605699-A1 | NEW COMPONENTS FOR ELECTROLYTE COMPOSITIONS | SOLVAY SA (BE) | 2020-02-05 | — | — | EP | disclosed |
| US-20190031616-A1 | HALOGEN SUBSTITUTED DIKETONES, PYRAZOLE COMPOUNDS AND PROCESSES FOR THE MANUFACTURE OF PYRAZOLE COMPOUNDS | SOLVAY SA (BE) | 2019-01-31 | — | — | US | disclosed |
| US-20100324073-A1 | Pyrazolo [1,5-A] Pyrimidine Compounds | WYETH LLC (US) | 2010-12-23 | — | — | US | disclosed |
| EP-2235020-A1 | PYRAZOLO [1,5-A] PYRIMIDINE COMPOUNDS | Wyeth LLC (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009086129-A1 | PYRAZOLO [1,5-A] PYRIMIDINE COMPOUNDS | WYETH (US) | 2009-07-09 | — | — | WO | disclosed |
| US-7329753-B2 | Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors | SCHERING AG (DE) | 2008-02-12 | — | — | US | disclosed |
| US-20060229333-A1 | Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2006-10-12 | — | — | US | disclosed |
| US-7109212-B2 | Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors | SCHERING AG (DE) | 2006-09-19 | — | — | US | disclosed |
| US-20050165050-A1 | Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2005-07-28 | — | — | US | disclosed |
| US-20050020564-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | ABBOTT LABORATORIES | 2005-01-27 | — | — | US | disclosed |
| US-20040220170-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | ABBOTT LABORATORIES | 2004-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324073-A1 | Pyrazolo [1,5-A] Pyrimidine Compounds | NR1H2, NR1H3, NR1H4 | TDP1 2035/4885CYP2C19 227/4885KDM4E 2850/4885 |
| US-20210040043-A1 | HALOGEN SUBSTITUTED DIKETONES, PYRAZOLE COMPOUNDS AND PROCESSES FOR THE MANUFACTURE OF PYRAZOLE COMPOUNDS | CYP3A4, PDXK, CYP3A43 | TDP1 3497/4885CYP2C19 12/4885KDM4E 1505/4885 |
| US-10829456-B2 | Halogen substituted diketones, pyrazole compounds and processes for the manufacture of pyrazole compounds | CYP3A4, PDXK, CYP3A43 | TDP1 3497/4885CYP2C19 12/4885KDM4E 1505/4885 |
| US-20190031616-A1 | HALOGEN SUBSTITUTED DIKETONES, PYRAZOLE COMPOUNDS AND PROCESSES FOR THE MANUFACTURE OF PYRAZOLE COMPOUNDS | CYP3A4, PDXK, CYP3A43 | TDP1 3497/4885CYP2C19 12/4885KDM4E 1505/4885 |
| US-20060229333-A1 | Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors | NFKBIA, IL1B, IRF3 | TDP1 3228/4885CYP2C19 379/4885KDM4E 3072/4885 |
| US-20050020564-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | SCN3A, KCNN3, TRPV3 | TDP1 3626/4885CYP2C19 3099/4885KDM4E 3210/4885 |
| US-20050165050-A1 | Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors | NFKBIA, IL1B, IRF3 | TDP1 3228/4885CYP2C19 379/4885KDM4E 3072/4885 |
| US-20040220170-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | SCN3A, KCNN3, TRPV3 | TDP1 3626/4885CYP2C19 3099/4885KDM4E 3210/4885 |
| US-20230242532-A1 | TETRACYCLIC PYRIMIDINONE COMPOUND, PREPARATION METHOD THEREFOR, AND COMPOSITION AND USE THEREOF | PLA2G1B, PLA2G5, PLA2G7 | TDP1 308/4885CYP2C19 2784/4885KDM4E 4433/4885 |
| US-20250011318-A1 | CBL-B INHIBITORS AND METHODS OF USE THEREOF | CBLB, CBL, CBLC | TDP1 1881/4885CYP2C19 4104/4885KDM4E 1545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.