Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8002521 | 0.82 | KMT2A (0.43) | KMT2AMEN1POLBALDH1A1TDP1 | |
| SCHEMBL6199512 | 0.78 | L3MBTL1 (0.33) | — | |
| SCHEMBL6971370 | 0.78 | KMT2A (0.68) | KMT2AMEN1POLBALDH1A1CA1 | |
| SCHEMBL9769366 | 0.77 | PTGS2 (0.41) | VCAM1KMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL58127 | 0.75 | HSD17B10 (0.54) | ALDH1A1TDP1HSD17B10 | |
| SCHEMBL57882 | 0.74 | TSHR (0.40) | KMT2AMEN1POLBALDH1A1TDP1 | |
| SCHEMBL2913624 | 0.73 | KMT2A (0.70) | KMT2AMEN1THRBPOLBALDH1A1 | |
| SCHEMBL2903043 | 0.73 | L3MBTL1 (0.38) | CA1CA2 | |
| SCHEMBL16961792 | 0.73 | ALDH1A1 (0.40) | KMT2AMEN1POLBALDH1A1TDP1 | |
| SCHEMBL6800906 | 0.72 | TDP1 (0.38) | KMT2AMEN1POLBALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709479-B1 | Quinazoline derivatives and their use as pharmaceuticals | ASTRAZENECA (SE) | 2010-05-04 | — | — | US | disclosed |
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |
| CN-1391562-A | Quinazoline derivatives as medicaments | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | CN | disclosed |
| EP-1218354-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021596-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |
| US-4277559-A | FOR MASKING UNWANTED BLUE ABSORPTION OF MAGENTA DYES WITHOUT PRODUCING EXCESSIVE FOG | AGFA-GEVAERT N.V. (BE) | 1981-07-07 | — | — | US | disclosed |