Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13225708 | 0.75 | ABCB11 (0.38) | ALDH1A1ABCB11THRBNR1I2CHRM2 | |
| SCHEMBL6487230 | 0.70 | ALDH1A1 (0.56) | ALDH1A1ABCB11THRBNR1I2CHRM2 | |
| SCHEMBL3538846 | 0.69 | ALOX5 (0.46) | ALDH1A1CYP2C19KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL15111367 | 0.68 | KMT2A (0.51) | ALDH1A1SLC6A4KMT2APOLBMEN1 | |
| SCHEMBL3533537 | 0.68 | LMNA (0.47) | ALDH1A1KMT2APOLBMEN1SMN1; SMN2 | |
| SCHEMBL28553916 | 0.68 | HPGD (0.43) | ALDH1A1KMT2AMEN1SMN1; SMN2HPGD | |
| SCHEMBL27641754 | 0.67 | ALDH1A1 (0.42) | ALDH1A1KMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL4064082 | 0.66 | ALDH1A1 (0.56) | ALDH1A1SLC6A4KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL15075786 | 0.66 | ABL1 (0.54) | ALDH1A1KMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL4510815 | 0.66 | NR3C2 (0.54) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101120000-B | Pyrazolopyrimidines | BAYER CROPSCIENCE AG | 2011-05-18 | — | — | CN | disclosed |
| US-7781439-B2 | Pyrazolopyrimidines | BAYER CROPSCIENCE AG (DE) | 2010-08-24 | — | — | US | disclosed |
| US-7781439-B2 | Pyrazolopyrimidines | BAYER CROPSCIENCE AG (DE) | 2010-08-24 | — | — | US | disclosed |
| US-7781439-B2 | Pyrazolopyrimidines | BAYER CROPSCIENCE AG (DE) | 2010-08-24 | — | — | US | disclosed |
| US-7629294-B2 | Pyrazolopyrimidines | BAYER CROPSCIENCE LP (DE) | 2009-12-08 | — | — | US | disclosed |
| US-7629294-B2 | Pyrazolopyrimidines | BAYER CROPSCIENCE LP (DE) | 2009-12-08 | — | — | US | disclosed |
| US-7629294-B2 | Pyrazolopyrimidines | BAYER CROPSCIENCE LP (DE) | 2009-12-08 | — | — | US | disclosed |
| US-20080287463-A1 | Pyrazolopyrimidines | BAYER CROPSCIENCE AG (DE) | 2008-11-20 | — | — | US | disclosed |
| US-20080287463-A1 | Pyrazolopyrimidines | BAYER CROPSCIENCE AG (DE) | 2008-11-20 | — | — | US | disclosed |
| US-20080287463-A1 | Pyrazolopyrimidines | BAYER CROPSCIENCE AG (DE) | 2008-11-20 | — | — | US | disclosed |
| CN-101120000-A | Pyrazolopyrimidines | BAYER CROPSCIENCE AG (DE) | 2008-02-06 | — | — | CN | disclosed |
| EP-1853607-A2 | PYRAZOLOPYRIMIDINES | Bayer CropScience AG (DE) | 2007-11-14 | — | — | EP | disclosed |
| CN-101023078-A | 5-heterocyclyl pyrimidines | BAYER CROPSCIENCE AG (DE) | 2007-08-22 | — | — | CN | disclosed |
| EP-1791834-A1 | 5-HETEROCYCLYL PYRIMIDINES | Bayer CropScience Aktiengesellschaft (DE) | 2007-06-06 | — | — | EP | disclosed |
| EP-1718652-A2 | PYRAZOLOPYRIMIDINES FOR COMBATTING UNWANTED MICROORGANISMS | Bayer CropScience Aktiengesellschaft (DE) | 2006-11-08 | — | — | EP | disclosed |
| WO-2006087120-A2 | PYRAZOLOPYRIMIDINES | BAYER CROPSCIENCE AG (DE) | 2006-08-24 | — | — | WO | disclosed |
| WO-2006029867-A1 | 5-HETEROCYCLYL PYRIMIDINES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2006-03-23 | — | — | WO | disclosed |
| WO-2005082907-A2 | PYRAZOLOPYRIMIDINES FOR CONTROLLING UNDESIRED MICROORGANISMS | BAYER CROPSCIENCE AG (DE) | 2005-09-09 | — | — | WO | disclosed |
| US-20050187224-A1 | Pyrazolopyrimidines | BAYER CROPSCIENCE AG (DE) | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287463-A1 | Pyrazolopyrimidines | RRP15, RPLP2, DPYD | ALDH1A1 891/4885ABCB11 2920/4885THRB 2739/4885 |
| US-20050187224-A1 | Pyrazolopyrimidines | P2RX5, P2RX4, P2RX1 | ALDH1A1 535/4885ABCB11 456/4885THRB 3504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.