Sugi Predict

Sugi Predict / Compounds / SCHEMBL3536504

SCHEMBL3536504

SCHEMBL3536504

c1ccc2c(-c3nc4ccncc4[nH]3)n[nH]c2c1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 6/20 0.73
▸ FLT1 P17948 6/20 0.73
▸ ITK Q08881 2/20 0.61
▸ CHEK1 O14757 2/20 0.60
▸ PDPK1 O15530 2/20 0.58
▸ CLK2 P49760 5/20 0.57
▸ DYRK1A Q13627 5/20 0.57
▸ CDK2 P24941 2/20 0.57
▸ PLK4 O00444 1/20 0.57
▸ AURKA O14965 1/20 0.57
▸ CHUK O15111 1/20 0.57
▸ JAK2 O60674 1/20 0.57
▸ ROCK2 O75116 1/20 0.57
▸ MAP4K4 O95819 1/20 0.57
▸ PAK4 O96013 1/20 0.57
▸ CHEK2 O96017 1/20 0.57
▸ ABL1 P00519 1/20 0.57
▸ NTRK1 P04629 1/20 0.57
▸ PRKCG P05129 1/20 0.57
▸ INSR P06213 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17555489 0.90 CLK2 (0.57) FGFR1FLT1ITKCHEK1PDPK1
SCHEMBL17556295 0.89 FGFR1 (0.73) FGFR1FLT1ITKCHEK1PDPK1
SCHEMBL17583341 0.89 FGFR1 (0.73) FGFR1FLT1ITKCHEK1PDPK1
SCHEMBL29381764 0.89 FGFR1 (0.73) FGFR1FLT1ITKCHEK1PDPK1
SCHEMBL311148 0.85 FGFR1 (1.00) FGFR1FLT1ITKCHEK1PDPK1
SCHEMBL29714859 0.85 FGFR1 (1.00) FGFR1FLT1ITKCHEK1PDPK1
SCHEMBL12369819 0.83 CLK2 (0.55) FGFR1FLT1CHEK1PDPK1CLK2
SCHEMBL3539728 0.82 KDM4E (0.58) FGFR1FLT1CHEK1PDPK1CLK2
SCHEMBL3538807 0.82 ALDH1A1 (0.58) FGFR1FLT1ITKCHEK1PDPK1
SCHEMBL3538139 0.81 ALDH1A1 (0.57) FGFR1FLT1ITKCHEK1PDPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060014756-A1 Benzimidazoles AVENTIS PHARMACEUTICALS INC. (US) 2006-01-19 — — US claimed
US-6897208-B2 Benzimidazoles AVENTIS PHARMACEUTICALS INC. (US) 2005-05-24 — — US claimed
EP-1441725-A1 BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS Aventis Pharmaceuticals Inc. (US) 2004-08-04 — — EP claimed
US-20040048868-A1 Benzimidazoles AVENTISUB LLC 2004-03-11 — — US claimed
WO-2003035065-A1 BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS AVENTIS PHARMACEUTICALS INC (US) 2003-05-01 — — WO claimed
US-20210292319-A1 2-(1H-INDAZOL-3-YL)-3H-IMIDAZO[4,5-C]PYRIDINES AND THEIR ANTI-INFLAMMATORY USES THEREOF VICKERS-SPLICE CO-INVESTMENT LLC (KY) 2021-09-23 — — US disclosed
EP-3371187-A4 2-(1H-INDAZOL-3-YL)-3H-IMIDAZO[4,5-C]PYRIDINES AND THEIR ANTI-INFLAMMATORY USES THEREOF Samumed, LLC (US) 2019-09-04 — — EP disclosed
US-20180318292-A1 2-(1H-INDAZOL-3-YL)-3H-IMIDAZO[4,5-C]PYRIDINES AND THEIR ANTI-INFLAMMATORY USES THEREOF VICKERS-SPLICE CO-INVESTMENT LLC (KY) 2018-11-08 — — US disclosed
EP-3371187-A1 2-(1H-INDAZOL-3-YL)-3H-IMIDAZO[4,5-C]PYRIDINES AND THEIR ANTI-INFLAMMATORY USES THEREOF Samumed, LLC (US) 2018-09-12 — — EP disclosed
EP-3371187-A1 2-(1H-INDAZOL-3-YL)-3H-IMIDAZO[4,5-C]PYRIDINES AND THEIR ANTI-INFLAMMATORY USES THEREOF Samumed, LLC (US) 2018-09-12 — — EP disclosed
WO-2017079759-A1 2-(1H-INDAZOL-3-YL)-3H-IMIDAZO[4,5-C]PYRIDINES AND THEIR ANTI-INFLAMMATORY USES THEREOF SAMUMED, LLC (US) 2017-05-11 — — WO disclosed
WO-2017079759-A1 2-(1H-INDAZOL-3-YL)-3H-IMIDAZO[4,5-C]PYRIDINES AND THEIR ANTI-INFLAMMATORY USES THEREOF SAMUMED, LLC (US) 2017-05-11 — — WO disclosed
US-7642278-B2 Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-01-05 — — US disclosed
US-7064215-B2 Indazole benzimidazole compounds CHIRON CORPORATION (US) 2006-06-20 — — US disclosed
US-20060079564-A1 Indazole benzimidazole compounds CHIRON CORPORATION 2006-04-13 — — US disclosed
US-20060014756-A1 Benzimidazoles AVENTIS PHARMACEUTICALS INC. (US) 2006-01-19 — — US disclosed
US-6897208-B2 Benzimidazoles AVENTIS PHARMACEUTICALS INC. (US) 2005-05-24 — — US disclosed
EP-1441725-A1 BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS Aventis Pharmaceuticals Inc. (US) 2004-08-04 — — EP disclosed
US-20040048868-A1 Benzimidazoles AVENTISUB LLC 2004-03-11 — — US disclosed
WO-2003035065-A1 BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS AVENTIS PHARMACEUTICALS INC (US) 2003-05-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060014756-A1 Benzimidazoles CDK9, BMX, SBK3 FGFR1 583/4885FLT1 2074/4885ITK 979/4885
US-20040048868-A1 Benzimidazoles CDK9, BMX, CDKN1A FGFR1 254/4885FLT1 1117/4885ITK 1317/4885
US-20060079564-A1 Indazole benzimidazole compounds ABL1, ABL2, ALK FGFR1 886/4885FLT1 2793/4885ITK 1055/4885
US-20180318292-A1 2-(1H-INDAZOL-3-YL)-3H-IMIDAZO[4,5-C]PYRIDINES AND THEIR ANTI-INFLAMMATORY USES THEREOF IL33, IL4, IL1B FGFR1 3013/4885FLT1 3048/4885ITK 902/4885
US-20210292319-A1 2-(1H-INDAZOL-3-YL)-3H-IMIDAZO[4,5-C]PYRIDINES AND THEIR ANTI-INFLAMMATORY USES THEREOF IL33, IL4, IL1B FGFR1 3013/4885FLT1 3048/4885ITK 902/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.