Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLQ | O75417 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL357050 | 0.82 | KDM4E (0.34) | HCRTR1HCRTR2KDM4EGRM5 | |
| SCHEMBL10207038 | 0.80 | MAPT (0.31) | KDM4EGRM5 | |
| SCHEMBL10167454 | 0.79 | POLB (0.35) | KDM4EGRM5 | |
| SCHEMBL10167485 | 0.79 | HCRTR1 (0.33) | HCRTR1HCRTR2GRM5 | |
| SCHEMBL352456 | 0.78 | HCRTR1 (0.39) | HCRTR1HCRTR2KDM4E | |
| SCHEMBL353442 | 0.77 | LMNA (0.36) | HCRTR1HCRTR2 | |
| SCHEMBL353612 | 0.74 | MEN1 (0.35) | HCRTR1HCRTR2KDM4E | |
| SCHEMBL353134 | 0.74 | HCRTR1 (0.39) | HCRTR1HCRTR2 | |
| SCHEMBL354766 | 0.73 | HCRTR1 (0.35) | HCRTR1HCRTR2 | |
| SCHEMBL352076 | 0.72 | HTR2C (0.34) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064196-B1 | 3-AMINO-1,2-BENZISOTHIAZOLE COMPOUNDS FOR COMBATING ANIMAL PEST II | BASF SE (DE) | 2012-03-14 | — | — | EP | disclosed |