Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.58 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.58 |
| ▸ | PARP1 | P09874 | 9/20 | 0.49 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TYMS | P04818 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GRK6 | P43250 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29882743 | 0.84 | ALOX15 (0.46) | KEAP1NFE2L2PARP1ALOX15TDP1 | |
| SCHEMBL1000050 | 0.84 | ALOX15 (0.46) | KEAP1NFE2L2PARP1ALOX15TDP1 | |
| SCHEMBL617136 | 0.82 | ALDH1A1 (0.56) | ALOX15TDP1TYMSALDH1A1KDM4E | |
| Phthalic Anhydride SCHEMBL17766645 | 0.82 | ALOX15 (0.61) | KEAP1NFE2L2PARP1BCAT2ALOX15 | |
| SCHEMBL10692219 | 0.81 | ALOX15 (0.48) | KEAP1NFE2L2ALOX15TDP1TYMS | |
| SCHEMBL3400362 | 0.81 | ALOX15 (0.43) | KEAP1NFE2L2PARP1ALOX15TDP1 | |
| SCHEMBL18301594 | 0.81 | PDK2 (0.44) | KEAP1NFE2L2PDK2ALOX15TDP1 | |
| Hydrochloric Acid SCHEMBL28875558 | 0.81 | ALDH1A1 (0.55) | ALOX15TDP1TYMSALDH1A1KDM4E | |
| SCHEMBL30037036 | 0.80 | KEAP1 (0.41) | KEAP1NFE2L2PARP1BCAT2AURKA | |
| SCHEMBL30037561 | 0.80 | KEAP1 (0.41) | KEAP1NFE2L2PARP1BCAT2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5094666-A | Ethylene polymer, amine salt or amide of carboxylic or dithiocarboxylic acid | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1992-03-10 | — | — | US | claimed |
| US-5092908-A | Composition for improving cold flow properties of middle distillates (OP-3571) | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1992-03-03 | — | — | US | claimed |
| EP-0465042-A1 | Composition for improving cold flow properties of middle distillates | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1992-01-08 | — | — | EP | claimed |
| US-7820697-B2 | Compositions and method for reducing TNFα levels | CELGENE CORPORATION (US) | 2010-10-26 | — | — | US | disclosed |
| US-20080287496-A1 | 1-Oxo- and 1,3-dioxoisoindolines and method of reducing inflammatory cytokine levels | CELGENE CORPORATION | 2008-11-20 | — | — | US | disclosed |
| US-20060030592-A1 | I-Oxo- and 1,3-dioxoisoindolines and method of reducing inflammatory cytokine levels | CELGENE CORPORATION | 2006-02-09 | — | — | US | disclosed |
| EP-1357120-A1 | 2-(2,6-dioxopiperidin-3-yl)isoindoline derivatives, their preparation and their use as inhibitors of inflammatory cytokines | CELGENE CORPORATION (US) | 2003-10-29 | — | — | EP | disclosed |
| US-20030028028-A1 | 1-oxo- and 1,3-dioxoisoindolines and method of reducing inflammatory cytokine levels | CELGENE CORPORATION | 2003-02-06 | — | — | US | disclosed |
| US-6403613-B1 | ANTI-INFLAMMATORY AGENT THAT REDUCES LEVELS OF CYTOKINES (INCLUDING TUMOR NECROSIS FACTOR) | CELGENE CORPORATION | 2002-06-11 | — | — | US | disclosed |
| US-20010006973-A1 | 1-OXO- AND 1,3-DIOXOISOINDOLINES AND METHOD OF REDUCING INFLAMMATORY CYTOKINE LEVELS | MAN HON-WAH (US) | 2001-07-05 | — | — | US | disclosed |
| EP-1064277-A1 | 2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF INFLAMMATORY CYTOKINES | Gelgene Corporation (US) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999047512-A1 | 2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF INFLAMMATORY CYTOKINES | COLGENE CORPORATION (US) | 1999-09-23 | — | — | WO | disclosed |
| EP-0288568-B1 | SHEET FOR RECEIVING THERMALLY TRANSFERRED IMAGE IN PREPARING A TRANSPARENT ORIGINAL | DAI NIPPON INSATSU KABUSHIKI KAISHA (JP) | 1993-06-16 | — | — | EP | disclosed |
| US-5053382-A | Heat sensitive recording | DAI NIPPON INSATSU KABUSHIKI KAISHA (JP) | 1991-10-01 | — | — | US | disclosed |
| US-4910188-A | Transparent substrate and receiver layers, support and tackifier layer | DAI NIPPON INSATSU KABUSHIKI KAISHA (JP) | 1990-03-20 | — | — | US | disclosed |
| US-4880768-A | NO DECREASE IN IMAGE DENSITY AFTER MULTIPLE USE | RICOH COMPANY, LTD. (JP) | 1989-11-14 | — | — | US | disclosed |
| EP-0288568-A1 | SHEET FOR RECEIVING THERMALLY TRANSFERRED IMAGE IN PREPARING A TRANSPARENT ORIGINAL | DAI NIPPON INSATSU KABUSHIKI KAISHA (JP) | 1988-11-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060030592-A1 | I-Oxo- and 1,3-dioxoisoindolines and method of reducing inflammatory cytokine levels | IL1A, IL1B, TNF | KEAP1 659/4885NFE2L2 244/4885PARP1 932/4885 |
| US-20080287496-A1 | 1-Oxo- and 1,3-dioxoisoindolines and method of reducing inflammatory cytokine levels | IL1A, IL1B, TNF | KEAP1 553/4885NFE2L2 256/4885PARP1 697/4885 |
| US-20010006973-A1 | 1-OXO- AND 1,3-DIOXOISOINDOLINES AND METHOD OF REDUCING INFLAMMATORY CYTOKINE LEVELS | TNF, IL1A, IL1B | KEAP1 696/4885NFE2L2 329/4885PARP1 944/4885 |
| US-20030028028-A1 | 1-oxo- and 1,3-dioxoisoindolines and method of reducing inflammatory cytokine levels | TNF, IL1A, IL1B | KEAP1 696/4885NFE2L2 329/4885PARP1 944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.