Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 6/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3541635 | 0.89 | MAPT (0.49) | POLBHTTMAPTKDM4EALDH1A1 | |
| SCHEMBL17844238 | 0.84 | SMN1; SMN2 (0.43) | POLBMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL5197239 | 0.79 | GSK3B (0.43) | POLBHTTMAPTKDM4EALDH1A1 | |
| SCHEMBL5184337 | 0.76 | MAOA (0.42) | POLBHTTALDH1A1HPGDUSP2 | |
| SCHEMBL5185824 | 0.74 | NPBWR1 (0.43) | POLBHTTMAPTKDM4EALDH1A1 | |
| SCHEMBL17844146 | 0.74 | HTR1B (0.39) | MAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL1997881 | 0.72 | TOP2A (0.42) | TOP2AALOX5POLBHTTMAPT | |
| SCHEMBL17844226 | 0.71 | MAPK1 (0.37) | HTTMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL17844229 | 0.66 | MEN1 (0.48) | POLBHTTMAPTKDM4EALDH1A1 | |
| SCHEMBL5724399 | 0.64 | NPC1 (0.64) | TOP2AALOX5MAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723333-B2 | Non-anilinic derivatives of isothiazol-3(2H)-one 1,1-dioxides as liver X receptor modulators | ASTRAZENECA AB (SE) | 2010-05-25 | — | — | US | claimed |
| WO-2016100619-A2 | TREATMENT AND DIAGNOSIS OF CANCER | RGENIX, INC. (US) | 2016-06-23 | — | — | WO | disclosed |