Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ASAH1 | Q13510 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TYMP | P19971 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | ASPH | Q12797 | 1/20 | 0.38 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5197239 | 0.84 | GSK3B (0.43) | MAOAMAOBKMT2AALDH1A1MEN1 | |
| SCHEMBL5185824 | 0.84 | NPBWR1 (0.43) | KMT2AALDH1A1HPGDMEN1L3MBTL1 | |
| SCHEMBL17844110 | 0.81 | MAOA (0.40) | MAOAMAOBSIGMAR1KMT2AASAH1 | |
| SCHEMBL5184329 | 0.81 | TYMP (0.42) | MAOAMAOBSIGMAR1KMT2AASAH1 | |
| SCHEMBL17844146 | 0.79 | HTR1B (0.39) | SIGMAR1L3MBTL1GPR84LMNA | |
| SCHEMBL17844216 | 0.76 | EPHX1 (0.40) | MAOAMAOBKMT2AASAH1MEN1 | |
| SCHEMBL17844226 | 0.75 | MAPK1 (0.37) | KMT2AALDH1A1HPGDMEN1LMNA | |
| SCHEMBL17844238 | 0.75 | SMN1; SMN2 (0.43) | KMT2AALDH1A1HPGDMEN1L3MBTL1 | |
| SCHEMBL17844195 | 0.73 | ASPH (0.41) | MAOAMAOBKMT2AALDH1A1HPGD | |
| SCHEMBL5224541 | 0.73 | GBA1 (0.44) | ALDH1A1ASAH1ASPHKDM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100619-A2 | TREATMENT AND DIAGNOSIS OF CANCER | RGENIX, INC. (US) | 2016-06-23 | — | — | WO | disclosed |
| EP-1838687-A1 | NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006073366-A1 | NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |