Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7959632 | 0.82 | TRPV4 (0.38) | TRPV4 | |
| SCHEMBL8189328 | 0.78 | TRPV4 (0.42) | TRPV4 | |
| SCHEMBL7812727 | 0.76 | CA1 (0.34) | — | |
| SCHEMBL6942963 | 0.76 | TSHR (0.54) | — | |
| SCHEMBL7812236 | 0.76 | ALDH1A1 (0.38) | — | |
| SCHEMBL788147 | 0.74 | TRPV4 (0.44) | TRPV4 | |
| SCHEMBL31556483 | 0.74 | TRPV4 (0.44) | TRPV4 | |
| SCHEMBL859436 | 0.74 | CYP3A4 (0.36) | — | |
| SCHEMBL16555423 | 0.74 | TRPV4 (0.40) | TRPV4 | |
| SCHEMBL8801063 | 0.73 | POLB (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097183-B1 | HIGH-RESISTANT CONDENSATION CROSS-LINKING SILICON | HEIDELBERGER BAUCHEMIE GMBH (DE) | 2002-04-10 | — | — | EP | claimed |
| US-7645759-B2 | Non-peptide bradykinin antagonists and pharmaceutical compositions therefrom | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 2010-01-12 | — | — | US | disclosed |
| US-7645759-B2 | Non-peptide bradykinin antagonists and pharmaceutical compositions therefrom | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 2010-01-12 | — | — | US | disclosed |
| EP-1513531-B1 | BASIC NON-PEPTIDE BRADYKININ ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS THEREFROM | MENARINI RICERCHE SPA (IT) | 2009-10-21 | — | — | EP | disclosed |
| US-7491825-B2 | Basic non-peptide bradykinin antagonists and pharmaceutical compositions therefrom | MENARINI RICERCHE S.P.A. (IT) | 2009-02-17 | — | — | US | disclosed |
| US-7491825-B2 | Basic non-peptide bradykinin antagonists and pharmaceutical compositions therefrom | MENARINI RICERCHE S.P.A. (IT) | 2009-02-17 | — | — | US | disclosed |
| EP-1799214-B8 | NON-PEPTIDE BRADYKININ ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS THEREFROM | LUSO FARMACO INST (IT) | 2008-06-18 | — | — | EP | disclosed |
| EP-1799214-B1 | NON-PEPTIDE BRADYKININ ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS THEREFROM | LUSO FARMACO INST (IT) | 2007-12-26 | — | — | EP | disclosed |
| US-20070281944-A1 | Non-peptide bradykinin antagonists and pharmaceutical compositions therefrom | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 2007-12-06 | — | — | US | disclosed |
| US-20070281944-A1 | Non-peptide bradykinin antagonists and pharmaceutical compositions therefrom | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 2007-12-06 | — | — | US | disclosed |
| US-20070281944-A1 | Non-peptide bradykinin antagonists and pharmaceutical compositions therefrom | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 2007-12-06 | — | — | US | disclosed |
| EP-1799214-A1 | NON-PEPTIDE BRADYKININ ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS THEREFROM | Instituto Luso Farmaco d'Italia S.P.A. (IT) | 2007-06-27 | — | — | EP | disclosed |
| US-20060205712-A1 | Basic non-peptide bradykinin antagonists and pharmaceutical compositions therefrom | MENARINI RIEERCHE S.P.A. (IT) | 2006-09-14 | — | — | US | disclosed |
| WO-2006040004-A1 | NON-PEPTIDE BRADYKININ ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS THEREFROM | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 2006-04-20 | — | — | WO | disclosed |
| EP-1513531-A1 | BASIC NON-PEPTIDE BRADYKININ ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS THEREFROM | Menarini Ricerche S.p.A. (IT) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003103671-A1 | BASIC NON-PEPTIDE BRADYKININ ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS THEREFROM | MENARINI RICERCHE S.P.A. (IT) | 2003-12-18 | — | — | WO | disclosed |
| US-6479515-B1 | FOR THE TREATMENT OF PAIN AND INFLAMMATION, AND ESPECIALLY IN THE TREATMENT OF ASTHMA, CEREBRAL TRAUMATIC SHOCK AND ALLERGIC RHINITIS | FOURNIER INDUSTRIE ET SANTE (FR) | 2002-11-12 | — | — | US | disclosed |
| US-6384222-B1 | BRADYKININ HORMONE ANTAGONIST; ANALGESIC, ANTIINFLAMMATORY; ASTHMA, CEREBRAL TRAUMATIC SHOCK AND ALLERGIC RHINITIS; ETHERIFICATION, AMIDATION | FOURNIER INDUSTRIE ET SANTE (FR) | 2002-05-07 | — | — | US | disclosed |
| US-6211181-B1 | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIALLERGENS, AND ANTIASTHMATICS | FOURNIER INDUSTRIE ET SANTE (FR) | 2001-04-03 | — | — | US | disclosed |
| US-6080758-A | ANALGESICS, ANTIINFLAMMATORY AGENTS; ASTHMA; ALLERGIC RHINITIS | FOURNIER INDUSTRIE ET SANTE (FR) | 2000-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281944-A1 | Non-peptide bradykinin antagonists and pharmaceutical compositions therefrom | BDKRB2, BDKRB1, BRS3 | TRPV4 164/4885 |
| US-20060205712-A1 | Basic non-peptide bradykinin antagonists and pharmaceutical compositions therefrom | BDKRB2, BDKRB1, AGTR2 | TRPV4 235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.