Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 7/20 | 0.74 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.74 |
| ▸ | FLT3 | P36888 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.52 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.51 |
| ▸ | XDH | P47989 | 1/20 | 0.49 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.49 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.48 |
| ▸ | F7 | P08709 | 1/20 | 0.48 |
| ▸ | F3 | P13726 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3559507 | 0.99 | PDGFRB (0.72) | PDGFRBPDGFRAFLT3KDM4EALDH1A1 | |
| SCHEMBL13853759 | 0.92 | PDGFRB (0.63) | PDGFRBPDGFRAFLT3KDM4EALDH1A1 | |
| SCHEMBL15223791 | 0.90 | PDGFRB (0.74) | PDGFRBPDGFRAFLT3KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL22289028 | 0.88 | PDGFRB (0.60) | PDGFRBPDGFRAFLT3KDM4EALDH1A1 | |
| SCHEMBL12287517 | 0.86 | PDGFRB (0.69) | PDGFRBPDGFRAFLT3KDM4EALDH1A1 | |
| SCHEMBL12392291 | 0.86 | PDGFRB (0.69) | PDGFRBPDGFRAFLT3KDM4EALDH1A1 | |
| SCHEMBL5472257 | 0.85 | PDGFRB (0.68) | PDGFRBPDGFRAFLT3KDM4EALDH1A1 | |
| SCHEMBL6868045 | 0.85 | PDGFRB (1.00) | PDGFRBPDGFRAFLT3KDM4EALDH1A1 | |
| SCHEMBL1144832 | 0.85 | KDM4E (0.65) | PDGFRBPDGFRAFLT3KDM4EALDH1A1 | |
| SCHEMBL4369016 | 0.85 | PLA2G4A (0.67) | PDGFRBPDGFRAFLT3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070105939-A1 | Mesylate salt of 5-(2-dimethylaminoethoxy)-1H-indole-2-carboxylic acid [3-(4-hydroxycarbamoylphenyl)prop-2-ynyl]amide | PHARMACYCLICS, INC. (US) | 2007-05-10 | — | — | US | claimed |
| US-20250262315-A1 | TRIPEPTIDE LINKERS AND METHODS OF USE THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2025-08-21 | — | — | US | disclosed |
| CN-113439084-B | Sesqui-carcinomycin analogue | 奥克兰联合服务有限公司 | 2025-02-25 | — | — | CN | disclosed |
| EP-4452292-A2 | TRIPEPTIDE LINKERS AND METHODS OF USE THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-10-30 | — | — | EP | disclosed |
| CN-118632857-A | Tripeptide linkers and methods of use thereof | 德克萨斯大学系统董事会 | 2024-09-10 | — | — | CN | disclosed |
| WO-2023122587-A2 | TRIPEPTIDE LINKERS AND METHODS OF USE THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-06-29 | — | — | WO | disclosed |
| EP-3500574-B1 | SECO-CYCLOPROPAPYRROLOINDOLE COMPOUNDS, ANTIBODY-DRUG CONJUGATES THEREOF, AND METHODS OF MAKING AND USE | BRISTOL MYERS SQUIBB CO (US) | 2021-11-24 | — | — | EP | disclosed |
| CN-113439084-A | Duocarmycin analogs | 奥克兰联合服务有限公司 | 2021-09-24 | — | — | CN | disclosed |
| WO-2020154437-A1 | GLYCOSIDE-CONTAINING PEPTIDE LINKERS FOR ANTIBODY-DRUG CONJUGATES | R.P. SCHERER TECHNOLOGIES, LLC (US) | 2020-07-30 | — | — | WO | disclosed |
| US-10287291-B2 | Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-05-14 | — | — | US | disclosed |
| US-20070105939-A1 | Mesylate salt of 5-(2-dimethylaminoethoxy)-1H-indole-2-carboxylic acid [3-(4-hydroxycarbamoylphenyl)prop-2-ynyl]amide | PHARMACYCLICS, INC. (US) | 2007-05-10 | — | — | US | disclosed |
| US-20070105939-A1 | Mesylate salt of 5-(2-dimethylaminoethoxy)-1H-indole-2-carboxylic acid [3-(4-hydroxycarbamoylphenyl)prop-2-ynyl]amide | PHARMACYCLICS, INC. (US) | 2007-05-10 | — | — | US | disclosed |
| US-20070105939-A1 | Mesylate salt of 5-(2-dimethylaminoethoxy)-1H-indole-2-carboxylic acid [3-(4-hydroxycarbamoylphenyl)prop-2-ynyl]amide | PHARMACYCLICS, INC. (US) | 2007-05-10 | — | — | US | disclosed |
| EP-1656348-B1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARM INC (US) | 2007-02-07 | — | — | EP | disclosed |
| EP-1656348-B1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARM INC (US) | 2007-02-07 | — | — | EP | disclosed |
| EP-1656348-A1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARMACEUTICALS, INC. (US) | 2006-05-17 | — | — | EP | disclosed |
| WO-2006043839-A1 | NITROBENZINDOLES AND THEIR USE IN CANCER THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2006-04-27 | — | — | WO | disclosed |
| US-20050131018-A1 | Acetylene derivatives as inhibitors of histone deacetylase | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-16 | — | — | US | disclosed |
| WO-2005019174-A1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-03 | — | — | WO | disclosed |
| WO-2005019174-A1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250262315-A1 | TRIPEPTIDE LINKERS AND METHODS OF USE THEREOF | DNPEP, VIP, LNPEP | PDGFRB 2969/4885PDGFRA 3214/4885FLT3 133/4885 |
| US-20070105939-A1 | Mesylate salt of 5-(2-dimethylaminoethoxy)-1H-indole-2-carboxylic acid [3-(4-hydroxycarbamoylphenyl)prop-2-ynyl]amide | HTR5A, HTR2B, HTR2A | PDGFRB 208/4885PDGFRA 323/4885FLT3 2371/4885 |
| US-20050131018-A1 | Acetylene derivatives as inhibitors of histone deacetylase | HDAC1, HDAC10, HDAC2 | PDGFRB 3829/4885PDGFRA 3581/4885FLT3 3864/4885 |
| US-10287291-B2 | Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use | CD22, GDI2, GDI1 | PDGFRB 2694/4885PDGFRA 2208/4885FLT3 3493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.