SCHEMBL355820

SCHEMBL355820

O=C1CCCc2ccc(Br)cc21

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 8/20 0.53
MAOB P27338 8/20 0.53
CYP2A6 P11509 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
PARP1 P09874 1/20 0.53
PARP10 Q53GL7 1/20 0.53
PRKCI P41743 1/20 0.52
PBRM1 Q86U86 1/20 0.50
MAPK1 P28482 2/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
HSD17B1 P14061 1/20 0.46
S100A4 P26447 1/20 0.43
ALDH1A1 P00352 1/20 0.42
LMNA P02545 1/20 0.42
MAPT P10636 1/20 0.42
METAP1 P53582 1/20 0.42
TYMS P04818 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29483386 1.00 MAOA (0.53) MAOAMAOBCYP2A6TDP1L3MBTL1
SCHEMBL24753297 0.96 PARP10 (0.53) MAOAMAOBCYP2A6TDP1L3MBTL1
SCHEMBL3006544 0.96 PARP10 (0.53) MAOAMAOBCYP2A6TDP1L3MBTL1
SCHEMBL27286 0.88 PBRM1 (0.64) MAOAMAOBTDP1L3MBTL1PARP1
SCHEMBL29804236 0.88 PBRM1 (0.64) MAOAMAOBTDP1L3MBTL1PARP1
SCHEMBL207834 0.84 MAOA (0.61) MAOAMAOBCYP2A6PARP10PRKCI
SCHEMBL16230083 0.84 TDP1 (0.63) MAOAMAOBCYP2A6TDP1L3MBTL1
SCHEMBL2065611 0.80 MAOA (0.59) MAOAMAOBCYP2A6PARP10PRKCI
SCHEMBL29983572 0.80 PBRM1 (0.78) MAOAMAOBCYP2A6PRKCIPBRM1
SCHEMBL29521431 0.80 MAOA (0.59) MAOAMAOBCYP2A6PARP10PRKCI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 713 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115108928-B Nitrogen mustard-tetralone derivative, preparation method and application thereof 广东海洋大学 2024-06-11 CN claimed
US-12641999-B2 Composition for organic optoelectronic device, organic optoelectronic device and display device SAMSUNG SDI CO., LTD. (KR) 2026-05-26 US disclosed
US-20260132132-A1 3A,4,5,6-TETRAHYDRO-1 H-PYRAZOLO[3,4-C]PYRIDIN-7(7AH)-ONE DERIVATIVES AS FACTOR XIIA INHIBITORS KALVISTA PHARMACEUTICALS LTD (GB) 2026-05-14 US disclosed
US-12628549-B2 Compound for organic optoelectronic device, composition for organic optoelectronic device, organic optoelectronic device and display device SAMSUNG SDI CO., LTD. (KR) 2026-05-12 US disclosed
US-12543495-B2 Composition, organic optoelectronic device and display device SAMSUNG SDI CO., LTD. (KR) 2026-02-03 US disclosed
US-20260022132-A1 SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS TREELINE BIOSCIENCES INC (US) 2026-01-22 US disclosed
EP-4658638-A1 SMALL MOLECULES FOR THE TREATMENT OF MYCOBACTERIAL DISEASES Council of Scientific and Industrial Research, an Indian Registered Body Incorporated under Regn. of Soc. Act (Act XXI of 1860) (IN) 2025-12-10 EP disclosed
WO-2025245127-A1 SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS Treeline Biosciences, Inc. (US) 2025-11-27 WO disclosed
US-20250325687-A1 CONJUGATE COMPRISING TOLL-LIKE RECEPTOR AGONIST MABSOFT THERAPEUTICS SHANGHAI CO LTD (CN) 2025-10-23 US disclosed
EP-4622716-A1 SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS Treeline Biosciences, Inc. (US) 2025-10-01 EP disclosed
US-4536343-A Process for preparing alpha-arylacrylonitriles ETHYL CORPORATION (US) 1985-08-20 US disclosed
EP-0135177-A2 Benzocycloalkane derivatives DAIICHI SEIYAKU CO., LTD. (JP) 1985-03-27 EP disclosed
US-4496572-A Benzo-fused thromboxane synthetase inhibitors PFIZER INC. (US) 1985-01-29 US disclosed
EP-0073663-A2 Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them Pfizer Limited (GB) 1983-03-09 EP disclosed
US-4374979-A Regiospecific synthesis of anthracyclinone compounds such as daunomycinone THE UNIVERSITY OF KANSAS ENDOWMENT ASSOCIATION (US) 1983-02-22 US disclosed
US-4226875-A Novel spiro-oxazolidinediones PFIZER INC. (US) 1980-10-07 US disclosed
US-4048330-A Compositions containing 2-(6'-substituted-2'-naphthyl)acetic acid esters used for treating inflammation, pain or pyrexia SYNTEX CORPORATION (US) 1977-09-13 US disclosed
US-4045485-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC AND ANTIPRURITIC ACTIVITY SYNTEX CORPORATION (US) 1977-08-30 US disclosed
US-3960936-A ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS, SKIN DISORDERS SYNTEX CORPORATION (PM) 1976-06-01 US disclosed
US-3947472-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTIPRURITIC SYNTEX CORPORATION (PM) 1976-03-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260132132-A1 3A,4,5,6-TETRAHYDRO-1 H-PYRAZOLO[3,4-C]PYRIDIN-7(7AH)-ONE DERIVATIVES AS FACTOR XIIA INHIBITORS F11, F13B, F7 MAOA 298/4885MAOB 88/4885CYP2A6 190/4885
US-12641999-B2 Composition for organic optoelectronic device, organic optoelectronic device and display device NR2E3, OXER1, NR0B2 MAOA 527/4885MAOB 197/4885CYP2A6 1049/4885
US-20260022132-A1 SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS KRAS, NRAS, G3BP2 MAOA 4501/4885MAOB 3147/4885CYP2A6 320/4885
US-12628549-B2 Compound for organic optoelectronic device, composition for organic optoelectronic device, organic optoelectronic device and display device OXER1, C1R, CHRM1 MAOA 961/4885MAOB 477/4885CYP2A6 1858/4885
US-20250325687-A1 CONJUGATE COMPRISING TOLL-LIKE RECEPTOR AGONIST TLR3, TLR7, TLR8 MAOA 2677/4885MAOB 2823/4885CYP2A6 4593/4885
US-12543495-B2 Composition, organic optoelectronic device and display device NR2E3, OXER1, ACVRL1 MAOA 285/4885MAOB 270/4885CYP2A6 401/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.