SCHEMBL27286

SCHEMBL27286

O=C1CCc2ccc(Br)cc21

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PBRM1 Q86U86 1/20 0.64
TDP1 Q9NUW8 1/20 0.61
L3MBTL1 Q9Y468 1/20 0.61
PARP10 Q53GL7 2/20 0.56
PARP1 P09874 1/20 0.56
S100A4 P26447 1/20 0.46
TYMS P04818 2/20 0.46
METAP1 P53582 1/20 0.44
CASP1 P29466 1/20 0.44
CASP7 P55210 1/20 0.44
HSD17B10 Q99714 1/20 0.44
TDP2 O95551 1/20 0.43
PARP11 Q9NR21 1/20 0.43
HSD17B1 P14061 1/20 0.43
SRD5A1 P18405 1/20 0.42
SRD5A2 P31213 1/20 0.42
BRD4 O60885 1/20 0.41
PTGS2 P35354 1/20 0.41
CMA1 P23946 1/20 0.41
AHR P35869 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29804236 1.00 PBRM1 (0.64) PBRM1TDP1L3MBTL1PARP10PARP1
SCHEMBL24753297 0.88 PARP10 (0.53) PBRM1TDP1L3MBTL1PARP10PARP1
SCHEMBL29483386 0.88 MAOA (0.53) PBRM1TDP1L3MBTL1PARP10PARP1
SCHEMBL3006544 0.88 PARP10 (0.53) PBRM1TDP1L3MBTL1PARP10PARP1
SCHEMBL355820 0.88 MAOA (0.53) PBRM1TDP1L3MBTL1PARP10PARP1
SCHEMBL16230083 0.88 TDP1 (0.63) PBRM1TDP1L3MBTL1PARP10PARP1
Formic Acid Methyl Ester SCHEMBL28108237 0.86 PBRM1 (0.50) PBRM1TDP1L3MBTL1PARP10PARP1
SCHEMBL358939 0.84 TDP1 (0.81) PBRM1TDP1L3MBTL1PARP10PARP1
SCHEMBL598138 0.84 TDP1 (0.61) PBRM1TDP1L3MBTL1PARP10PARP1
SCHEMBL27039 0.83 CASP1 (0.59) PBRM1TDP1L3MBTL1PARP10S100A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 905 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118878820-A Photocatalytic stilbene synthesized porous poly schiff base material and dye adsorption application 安徽中天新材料科技股份有限公司 2024-11-01 CN claimed
CN-115724834-A Indenoquinolinone or chromene quinolinone derivative and preparation method and application thereof 广东工业大学 2023-03-03 CN claimed
CN-113861113-B Preparation and application of fused ring pyridine compound and derivative thereof 中国科学院福建物质结构研究所 2022-12-06 CN claimed
CN-113861113-A Preparation and application of fused ring pyridine compound and derivative thereof 中国科学院福建物质结构研究所 2021-12-31 CN claimed
CN-113321617-A Red light thermal induction delay fluorescent material, preparation method thereof and organic electroluminescent device 中国科学院长春应用化学研究所 2021-08-31 CN claimed
CN-112574078-A 2-sulfuryl-2, 3-dihydro-1-indanone and derivatives and synthesis method thereof 湖南工程学院 2021-03-30 CN claimed
CN-112029743-A Bio-enzyme catalytic synthesis method of 6-bromoindanone 江西邦泰绿色生物合成生态产业园发展有限公司 2020-12-04 CN claimed
EP-3064494-A1 A PROCESS FOR THE PREPARATION OF A CAMSYLATE SALT ((1S)-(+)-10 CAMPHORSULFONIC ACID) OF (1R,1'R,4R)- 4-METHOXY-5\"-METHYL-6'-[5-(PROP-1-YN-1-YL)PYRIDIN- 3-YL]-3'H-DISPIRO[CYCLOHEXANE-1,2'-INDEN-1'2'-IMIDAZOLE]-4\"-AMINE AstraZeneca AB (SE) 2016-09-07 EP claimed
EP-4737455-A1 COMPOUND CONTAINING MULTI-FUSED RING STRUCTURE Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) 2026-05-06 EP disclosed
US-20260098028-A1 Compounds and Their Use for Treatment of Hemoglobinopathies BRISTOL-MYERS SQUIBB COMPANY (US) 2026-04-09 US disclosed
US-20260098037-A1 COMPOUND CONTAINING MULTI-FUSED RING STRUCTURE CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) 2026-04-09 US disclosed
EP-3950676-B1 PREPARATION METHOD FOR AMIDE COMPOUNDS AND APPLICATION THEREOF IN FIELD OF MEDICINE SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO LTD (CN) 2026-04-08 EP disclosed
US-12595267-B2 Preparation method for amide compound and application thereof in field of medicine SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD. (CN) 2026-04-07 US disclosed
EP-3950682-B1 PREPARATION METHOD FOR AMIDE COMPOUNDS AND USE THEREOF IN MEDICAL FIELD SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO LTD (CN) 2026-02-11 EP disclosed
WO-1994026692-A1 BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS THE WELLCOME FOUNDATION LIMITED (GB) 1994-11-24 WO disclosed
EP-0357742-B1 NEW PYRETHRINOID ESTERS CARRYING AN INDANYL RING, PREPARATION METHOD AND APPLICATION AS PESTICIDES ROUSSEL-UCLAF (FR) 1993-06-09 EP disclosed
EP-0240859-B1 LIPOXYGENASE INHIBITING COMPOUNDS ABBOTT LABORATORIES (US) 1993-04-28 EP disclosed
US-5180741-A Insecticides ROUSSEL UCLAF (FR) 1993-01-19 US disclosed
EP-0357742-A1 NEW PYRETHRINOID ESTERS CARRYING AN INDANYL RING, PREPARATION METHOD AND APPLICATION AS PESTICIDES. ROUSSEL UCLAF (FR) 1990-03-14 EP disclosed
WO-1989008096-A1 NEW PYRETHRINOID ESTERS CARRYING AN INDANYL RING, PREPARATION METHOD AND APPLICATION AS PESTICIDES ROUSSEL-UCLAF (FR) 1989-09-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12595267-B2 Preparation method for amide compound and application thereof in field of medicine EZH2, BMI1, EHMT1 PBRM1 51/4885TDP1 3871/4885L3MBTL1 1175/4885
US-20260098037-A1 COMPOUND CONTAINING MULTI-FUSED RING STRUCTURE SLC5A2, SLC5A11, SLC5A1 PBRM1 2464/4885TDP1 3935/4885L3MBTL1 4806/4885
US-20260098028-A1 Compounds and Their Use for Treatment of Hemoglobinopathies HBZ, HBG2, HBB PBRM1 3544/4885TDP1 4327/4885L3MBTL1 2154/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.