SCHEMBL3568166

SCHEMBL3568166

CC(=O)NC[C@H]1CN(c2ccc(N3CCC(=O)CC3)c(F)c2)C(=O)O1

nearest known ligand 0.82

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOA P21397 6/20 0.82
MAOB P27338 6/20 0.82
PTGS1 P23219 2/20 0.82
SDHA P31040 2/20 0.82
LMNA P02545 1/20 0.82
CALML3 P27482 1/20 0.82
F10 P00742 7/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3185881 1.00 MAOA (0.82) MAOAMAOBPTGS1SDHALMNA
SCHEMBL6987852 0.96 MAOA (0.76) MAOAMAOBPTGS1SDHALMNA
SCHEMBL6987847 0.96 MAOA (0.76) MAOAMAOBPTGS1SDHALMNA
SCHEMBL7811281 0.94 MAOA (0.76) MAOAMAOBPTGS1SDHALMNA
SCHEMBL6851173 0.94 MAOA (0.76) MAOAMAOBPTGS1SDHALMNA
SCHEMBL4181827 0.93 MAOA (0.71) MAOAMAOBPTGS1SDHALMNA
SCHEMBL4181831 0.93 MAOA (0.71) MAOAMAOBPTGS1SDHALMNA
SCHEMBL8799139 0.92 MAOA (0.79) MAOAMAOBPTGS1SDHALMNA
SCHEMBL8799125 0.92 MAOA (0.79) MAOAMAOBPTGS1SDHALMNA
SCHEMBL6988071 0.91 MAOA (0.83) MAOAMAOBPTGS1SDHALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0750618-B1 OXAZOLIDINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM UPJOHN CO (US) 2003-02-19 EP claimed
US-8729269-B2 Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy WOCKHARDT LIMITED (IN) 2014-05-20 US disclosed
US-20100144735-A1 SUBSTITUTED PIPERIDINO PHENYLOXAZOLIDINONES HAVING ANTIMICROBIAL ACTIVITY WITH IMPROVED IN VIVO EFFICACY WOCKHARDT LIMITED 2010-06-10 US disclosed
US-7687627-B2 Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy WOCKHARDT LIMITED (IN) 2010-03-30 US disclosed
US-7405228-B2 Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoprotein sites WOCKHARDT LIMITED (IN) 2008-07-29 US disclosed
EP-1664038-A2 SUBSTITUTED PIPERIDINO PHENYLOXAZOLIDINONES HAVING ANTIMICRIOBIAL ACTIVITY WITH IMPROVED I IN VIVO /I EFFICACY Wockhardt Limited (IN) 2006-06-07 EP disclosed
EP-1565461-A2 ANTIBACTERIAL SUBSTITUTED CYANOMETHYL(ENE)PIPERIDINOPHENYL OXAZOLIDINONES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Patel, Mahesh V. (IN) 2005-08-24 EP disclosed
US-20050143421-A1 Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy WOCKHARDT LIMITED 2005-06-30 US disclosed
EP-1546140-A2 ANTIMICROBIAL OXAZOLIDINONES, PROCESS OF THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Wockhardt Limited (IN) 2005-06-29 EP disclosed
WO-2005054234-A2 SUBSTITUTED PIPERIDINO PHENYLOXAZOLIDINONES HAVING ANTIMICRIOBIAL ACTIVITY WITH IMPROVED IN VIVO EFFICACY WOCKHARDT LIMITED (IN) 2005-06-16 WO disclosed
US-20040063954-A1 Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoprotein sites WOCKHARDT LIMITED 2004-04-01 US disclosed
WO-2004007489-A2 ANTIBACTERIAL SUBSTITUTED CYANOMETHYL (ENE) PIPERIDINOPHENYL OXAZOLIDINONES, PROCESS OR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM WOCKHARDT LIMITED (IN) 2004-01-22 WO disclosed
WO-2004007488-A2 ANTIMICROBIAL OXAZOLIDINONES, PROCESS OF THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM WOCKHARDT LIMITED (IN) 2004-01-22 WO disclosed
EP-1030852-B1 OXAZOLIDINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS UPJOHN CO (US) 2003-09-17 EP disclosed
WO-2003074597-A1 PROTON CONDUCTING ELECTROLYTE MEMBRANE HAVING REDUCED METHANOL PERMEABILITY AND THE USE THEREOF IN FUEL CELLS PEMEAS GMBH (DE) 2003-09-12 WO disclosed
EP-0750618-B1 OXAZOLIDINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM UPJOHN CO (US) 2003-02-19 EP disclosed
US-5998406-A BACTERICIDES PHARMACIA & UPJOHN COMPANY (US) 1999-12-07 US disclosed
US-5668286-A ANTIBIOTIC PHARMACIA & UPJOHN COMPANY (US) 1997-09-16 US disclosed
EP-0750618-A1 OXAZOLIDINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PHARMACIA & UPJOHN COMPANY (US) 1997-01-02 EP disclosed
WO-1995025106-A1 OXAZOLIDINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PHARMACIA & UPJOHN COMPANY (US) 1995-09-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100144735-A1 SUBSTITUTED PIPERIDINO PHENYLOXAZOLIDINONES HAVING ANTIMICROBIAL ACTIVITY WITH IMPROVED IN VIVO EFFICACY GMPS, MPO, ARG1 MAOA 2638/4885MAOB 2975/4885PTGS1 170/4885
US-20050143421-A1 Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy GMPS, MPO, ARG1 MAOA 2638/4885MAOB 2975/4885PTGS1 170/4885
US-20040063954-A1 Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoprotein sites POLRMT, RNASEL, RNASE1 MAOA 1873/4885MAOB 2080/4885PTGS1 3036/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.