Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576626 | 0.90 | RXFP1 (0.41) | HDAC8HDAC1RXFP1KMT2AHDAC11 | |
| SCHEMBL3575609 | 0.89 | LMNA (0.43) | HDAC8HDAC1TRPV1KMT2AHDAC11 | |
| SCHEMBL3570220 | 0.87 | KDM5A (0.40) | KMT2ASLC2A1PPARGPPARANR1H4 | |
| SCHEMBL3575602 | 0.87 | LPAR1 (0.38) | HDAC1KMT2AHDAC11HDAC6PPARG | |
| SCHEMBL3581450 | 0.85 | MEP1B (0.41) | KMT2ASLC2A1PTGESMEN1PPARG | |
| SCHEMBL3576619 | 0.85 | SLC2A1 (0.43) | HDAC8HDAC1TRPV1RXFP1KMT2A | |
| SCHEMBL3579370 | 0.85 | SLC2A1 (0.39) | HDAC8HDAC1TRPV1KMT2AHDAC11 | |
| SCHEMBL3575452 | 0.84 | KMT2A (0.42) | KMT2AMEN1PPARGPPARANR1H4 | |
| SCHEMBL12521085 | 0.84 | HDAC8 (0.42) | HDAC8HDAC1KMT2AHDAC11HDAC6 | |
| SCHEMBL3570707 | 0.84 | C5AR1 (0.39) | KMT2APPARGNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |