Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.38 |
| ▸ | ESRRG | P62508 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3578799 | 0.88 | TP53 (0.39) | LPAR1LPAR5ESRRGTP53MAPT | |
| SCHEMBL3579507 | 0.87 | HDAC8 (0.41) | NR1H4KMT2APPARGHDAC6HDAC1 | |
| SCHEMBL3570707 | 0.86 | C5AR1 (0.39) | LPAR1LPAR5ESRRGTP53MAPT | |
| SCHEMBL3583652 | 0.84 | EPHX2 (0.38) | LPAR1LPAR5ESRRGTP53MAPT | |
| SCHEMBL3575452 | 0.83 | KMT2A (0.42) | ESRRGNR1H4KMT2APPARG | |
| SCHEMBL3570220 | 0.82 | KDM5A (0.40) | LPAR1LPAR5NR1H4EPHX2KMT2A | |
| SCHEMBL3587595 | 0.81 | C5AR1 (0.49) | LPAR1LPAR5ESRRGNR1H4KMT2A | |
| SCHEMBL3581450 | 0.80 | MEP1B (0.41) | LPAR1LPAR5MAPTNR1H4KMT2A | |
| SCHEMBL3574076 | 0.78 | HDAC1 (0.52) | LPAR1LPAR5HDAC6HDAC1HDAC11 | |
| SCHEMBL3581107 | 0.78 | RAB9A (0.37) | ESRRGTP53MAPTNR1H4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |