Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | GPR6 | P46095 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.32 |
| ▸ | PYGL | P06737 | 1/20 | 0.31 |
| ▸ | MLYCD | O95822 | 1/20 | 0.31 |
| ▸ | TACR2 | P21452 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3583620 | 0.91 | MCHR1 (0.40) | MCHR1CRHR1C5AR1TACR1 | |
| SCHEMBL3580209 | 0.91 | MCHR1 (0.40) | MCHR1CRHR1OPRM1OPRD1 | |
| SCHEMBL3576670 | 0.90 | MCHR1 (0.38) | MCHR1CRHR1 | |
| SCHEMBL3574238 | 0.88 | MLYCD (0.35) | TRPM8OPRM1OPRD1C5AR1MLYCD | |
| SCHEMBL3577036 | 0.86 | MCHR1 (0.43) | MCHR1OPRM1OPRD1C5AR1PYGL | |
| SCHEMBL3576972 | 0.84 | BTK (0.36) | CRHR1GPR6OPRM1OPRD1 | |
| SCHEMBL3586536 | 0.82 | MCHR1 (0.37) | MCHR1CRHR1 | |
| SCHEMBL3584062 | 0.81 | GBA1 (0.34) | OPRM1OPRD1MLYCDTRPV1 | |
| SCHEMBL3569329 | 0.80 | C5AR1 (0.41) | C5AR1MLYCD | |
| SCHEMBL3576692 | 0.79 | ESRRG (0.37) | TRPM8OPRM1OPRD1C5AR1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |