Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.65 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1911102 | 1.00 | TRPA1 (0.65) | TRPA1TAAR1SIGMAR1SLC6A2MAOA | |
| SCHEMBL94629 | 1.00 | TRPA1 (0.65) | TRPA1TAAR1SIGMAR1SLC6A2MAOA | |
| SCHEMBL110694 | 0.89 | TRPA1 (0.59) | TRPA1TAAR1SIGMAR1SLC6A2MAOA | |
| SCHEMBL17171333 | 0.89 | TRPA1 (0.59) | TRPA1TAAR1SIGMAR1SLC6A2MAOA | |
| SCHEMBL8283173 | 0.87 | TRPA1 (0.52) | TRPA1CYP2D6 | |
| Phthalic Acid SCHEMBL28282618 | 0.87 | TRPA1 (0.52) | TRPA1CYP3A4MAPK1NPC1RAB9A | |
| SCHEMBL4785594 | 0.85 | SIGMAR1 (0.64) | TRPA1TAAR1SIGMAR1SLC6A2MAOA | |
| SCHEMBL11434236 | 0.82 | LTA4H (0.58) | TRPA1 | |
| SCHEMBL357349 | 0.82 | MAOB (0.57) | SIGMAR1SLC6A2MAOASLC6A3 | |
| SCHEMBL360368 | 0.82 | MAOB (0.57) | SIGMAR1SLC6A2MAOASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11702444-B2 | Method for preparing natural bioactive peptide Tubulysin U | SHENZHEN INSTITUTE OF GERIATRICS (CN) | 2023-07-18 | — | — | US | disclosed |
| US-11685734-B2 | ATM kinase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2023-06-27 | — | — | US | disclosed |
| EP-3906232-B1 | PROCESS FOR THE DIFFERENTIAL SOLUBILITY-DRIVEN ASYMMETRIC TRANSFORMATION OF SUBSTITUTED 2H-CHROMENE-3-CARBOXYLIC ACIDS | ASKAT INC (JP) | 2023-05-10 | — | — | EP | disclosed |
| US-20190248785-A1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | SHIONOGI & CO., LTD. (JP) | 2019-08-15 | — | — | US | disclosed |
| EP-2791142-B1 | COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS | US HEALTH (US) | 2019-07-03 | — | — | EP | disclosed |
| WO-2018140630-A1 | AUTOPHAGY INDUCERS FOR TREATMENT OF CNS CONDITIONS | NORTHWESTERN UNIVERSITY (US) | 2018-08-02 | — | — | WO | disclosed |
| US-20180170889-A1 | Simplified Structural Mimetics of AIPS as Quorum Sensing Inhibitors | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2018-06-21 | — | — | US | disclosed |
| US-9815835-B2 | Substituted polycyclic carbamolypyridone derivative | SHIONOGI & CO., LTD. (JP) | 2017-11-14 | — | — | US | disclosed |
| US-20170260192-A1 | COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT OF HEALTH AND HUMAN SERVICES (US) | 2017-09-14 | — | — | US | disclosed |
| US-9758515-B2 | Substituted polycyclic carbamoyl pyridone derivative prodrug | SHIONOGI & CO., LTD. (JP) | 2017-09-12 | — | — | US | disclosed |
| WO-2007121920-A2 | PURINE DERIVATIVES FOR USE AS ADENOSIN A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2007-11-01 | — | — | WO | disclosed |
| WO-2007121923-A1 | PURINE DERIVATIVES AS A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2007-11-01 | — | — | WO | disclosed |
| WO-2007103755-A2 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |
| EP-1534712-B1 | PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-05-16 | — | — | EP | disclosed |
| US-7189864-B2 | Method of preparing intermediates useful in synthesis of retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2007-03-13 | — | — | US | disclosed |
| WO-2006021213-A2 | VASOPRESSIN V1A ANTAGONISTS | FERRING B.V. (NL) | 2006-03-02 | — | — | WO | disclosed |
| EP-0817770-A1 | NONPEPTIDES AS TACHYKININ ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-01-14 | — | — | EP | disclosed |
| EP-0492401-B1 | Asymmetric hydrogenation | CIBA GEIGY AG (CH) | 1996-01-24 | — | — | EP | disclosed |
| US-5288928-A | Using neutal or cationic rhodium complex of a chiral atropisomeric diphosphine ligand as catalyst | CIBA-GEIGY CORPORATION (US) | 1994-02-22 | — | — | US | disclosed |
| EP-0492401-A1 | Asymmetric hydrogenation | CIBA-GEIGY AG (CH) | 1992-07-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170260192-A1 | COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS | PGF, BRCA1, RB1 | TRPA1 3313/4885TAAR1 3340/4885SIGMAR1 2349/4885 |
| US-11685734-B2 | ATM kinase inhibitors and compositions and methods of use thereof | ATM, CHEK2, CHEK1 | TRPA1 4790/4885TAAR1 4112/4885SIGMAR1 4716/4885 |
| US-20190248785-A1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | PREP, UNG, DPP4 | TRPA1 4750/4885TAAR1 4505/4885SIGMAR1 2781/4885 |
| US-20180170889-A1 | Simplified Structural Mimetics of AIPS as Quorum Sensing Inhibitors | AIP, AIPL1, CGAS | TRPA1 993/4885TAAR1 3070/4885SIGMAR1 3642/4885 |
| US-11702444-B2 | Method for preparing natural bioactive peptide Tubulysin U | VIP, MLN, HNRNPU | TRPA1 729/4885TAAR1 257/4885SIGMAR1 3052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.