Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TYMS | P04818 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3572326 | 0.94 | TYMS (0.39) | ALDH1A1CYP3A4ALOX15TDP1TYMS | |
| SCHEMBL3572332 | 0.84 | CYP3A4 (0.33) | ALDH1A1CYP3A4ALOX15TDP1TYMS | |
| SCHEMBL3634693 | 0.81 | MAPT (0.40) | ALDH1A1CYP3A4ALOX15TDP1MAPK1 | |
| SCHEMBL3574966 | 0.77 | ITGA4 (0.35) | ALDH1A1CYP3A4ALOX15TDP1MAPK1 | |
| Trifluoroacetic Acid SCHEMBL3585015 | 0.77 | MAPT (0.36) | ALDH1A1CYP3A4ALOX15TDP1TYMS | |
| SCHEMBL21422767 | 0.73 | MAPT (0.37) | ALDH1A1CYP3A4ALOX15TDP1TYMS | |
| SCHEMBL5925568 | 0.72 | CA2 (0.52) | ALDH1A1CYP3A4TDP1CA2CA1 | |
| SCHEMBL9828354 | 0.71 | CTSD (0.55) | ALDH1A1CYP3A4TYMSCA2CA1 | |
| SCHEMBL27456509 | 0.71 | CTSD (0.55) | ALDH1A1CYP3A4TYMSCA2CA1 | |
| SCHEMBL28907592 | 0.70 | DHFR (0.53) | ALDH1A1TYMSCA2CA1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150514-B1 | 18F-LABELLED FOLATES | Merck & Cie (CH) | 2018-10-24 | — | — | EP | disclosed |
| US-9771368-B2 | 18F-labelled folates | Merck & Cie (CH) | 2017-09-26 | — | — | US | disclosed |
| US-20160159802-A1 | 18F-LABELLED FOLATES | Merck & Cie (CH) | 2016-06-09 | — | — | US | disclosed |
| US-9315506-B2 | 18F-labelled folates | Merck & Cie (CH) | 2016-04-19 | — | — | US | disclosed |
| US-20100056533-A1 | 18F-LABELLED FOLATES | MERCK EPROVA AG (CH) | 2010-03-04 | — | — | US | disclosed |
| EP-2150514-A2 | 18F-LABELLED FOLATES | Merck Eprova AG (CH) | 2010-02-10 | — | — | EP | disclosed |
| CN-101646670-A | 18F-labelled folates | MERCK EPROVA AG CH | 2010-02-10 | — | — | CN | disclosed |
| WO-2008125617-A2 | 18F-LABELLED FOLATES | MERCK EPROVA AG (CH) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056533-A1 | 18F-LABELLED FOLATES | FOLR1, FOLR2, SLC19A1 | ALDH1A1 1012/4885CYP3A4 1686/4885ALOX15 996/4885 |
| US-20160159802-A1 | 18F-LABELLED FOLATES | FOLR1, FOLR2, SLC19A1 | ALDH1A1 942/4885CYP3A4 2092/4885ALOX15 835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.