Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.42 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3587595 | 0.84 | C5AR1 (0.49) | HDAC1HDAC6LPAR1LPAR5 | |
| SCHEMBL3575452 | 0.81 | KMT2A (0.42) | HSP90AA1 | |
| SCHEMBL3579507 | 0.79 | HDAC8 (0.41) | HDAC1HDAC6HDAC8HDAC11 | |
| SCHEMBL3578799 | 0.79 | TP53 (0.39) | LPAR1LPAR5 | |
| SCHEMBL3570707 | 0.79 | C5AR1 (0.39) | HSP90AA1LPAR1LPAR5 | |
| SCHEMBL3581107 | 0.78 | RAB9A (0.37) | — | |
| SCHEMBL3575602 | 0.78 | LPAR1 (0.38) | HDAC1HDAC6HDAC11LPAR1LPAR5 | |
| SCHEMBL3577669 | 0.78 | HDAC1 (0.43) | HDAC1HDAC6HDAC3HDAC2LTB4R2 | |
| SCHEMBL3583652 | 0.77 | EPHX2 (0.38) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL3581450 | 0.77 | MEP1B (0.41) | LPAR1LPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |