Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5644713 | 0.87 | CYP1A2 (0.55) | CYP1A2CYP2C9CYP2C19HTTSIRT5 | |
| SCHEMBL28035078 | 0.86 | TP53 (0.58) | CYP1A2CYP2C9CYP2C19HTTSIRT5 | |
| SCHEMBL1258879 | 0.83 | CYP4F2 (0.58) | CYP1A2CYP2C9CYP2C19HTTSIRT5 | |
| SCHEMBL13065907 | 0.82 | L3MBTL1 (0.55) | CYP1A2CYP2C9CYP2C19HTTSIRT5 | |
| SCHEMBL111429 | 0.81 | L3MBTL1 (0.54) | HTTSIRT5TP53POLBLMNA | |
| SCHEMBL28179453 | 0.81 | ALDH1A1 (0.51) | CYP1A2CYP2C9CYP2C19HTTSIRT5 | |
| SCHEMBL9257247 | 0.80 | CYP1A2 (0.48) | CYP1A2CYP2C9CYP2C19HTTSIRT5 | |
| SCHEMBL5009129 | 0.80 | ALOX5 (0.50) | CYP1A2CYP2C9CYP2C19SIRT5SMN1; SMN2 | |
| SCHEMBL31115245 | 0.80 | CYP1A2 (0.55) | CYP1A2CYP2C9CYP2C19HTTSIRT5 | |
| SCHEMBL13539596 | 0.79 | CYP1A2 (0.52) | CYP1A2CYP2C9CYP2C19HTTSIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 177 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE30655-E | Process for preparing 3-thienyl-acetate derivatives | LABAZ (FR) | 1981-06-23 | — | — | US | claimed |
| US-4186137-A | ALKYLATION WITH CYCLOHEXYL BROMIDE | LABAZ (FR) | 1980-01-29 | — | — | US | claimed |
| US-20250171459-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMA (US) | 2025-05-29 | — | — | US | disclosed |
| EP-4476227-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | Vertex Pharmaceuticals Incorporated (US) | 2024-12-18 | — | — | EP | disclosed |
| CN-111018790-B | Pyridazinone herbicides | FMC公司 | 2023-09-19 | — | — | CN | disclosed |
| WO-2023154344-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |
| WO-2023154344-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |
| CN-116425706-A | Preparation method of caronic anhydride | 能特科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-112724127-B | Five-membered heterocyclic oxocarboxylic acid compound and medical application thereof | 中国科学院上海药物研究所 | 2023-02-17 | — | — | CN | disclosed |
| US-20230032101-A1 | FIVE-MEMBERED HETEROCYCLIC OXOCARBOXYLIC ACID COMPOUND AND MEDICAL USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2023-02-02 | — | — | US | disclosed |
| US-20220363709-A1 | ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE THEREOF | ANTENGENE THERAPEUTICS LIMITED (CN) | 2022-11-17 | — | — | US | disclosed |
| US-5518767-A | P-DOPED CONJUGATED POLYMER MONOLAYER WITH POLYANION BOUND ELECTROSTATICALLY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1996-05-21 | — | — | US | disclosed |
| WO-1995002251-A2 | MOLECULAR SELF-ASSEMBLY OF ELECTRICALLY CONDUCTIVE POLYMERS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1995-01-19 | — | — | WO | disclosed |
| EP-0234688-A1 | Thiophene-3-carboxaldehyde derivatives, their preparation and their use in preparing 3-thienyl acetonitrile | BEECHAM GROUP PLC (GB) | 1987-09-02 | — | — | EP | disclosed |
| EP-0002846-B1 | 3-THIENYLMALONIC ACIDS, THE CORRESPONDING DIESTERS AND THEIR PREPARATION | Océ-Andeno B.V. (NL) | 1984-05-23 | — | — | EP | disclosed |
| US-4287291-A | SATURATED ALIPHATIC OR ALICYCLIC ALCOHOL IN PROCESSING SOLUTION | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1981-09-01 | — | — | US | disclosed |
| US-RE30655-E | Process for preparing 3-thienyl-acetate derivatives | LABAZ (FR) | 1981-06-23 | — | — | US | disclosed |
| US-4262129-A | Preparation of a 3-thienylmalonic acid and the corresponding diesters | OCE-ANDENO B.V. (NL) | 1981-04-14 | — | — | US | disclosed |
| US-4186137-A | ALKYLATION WITH CYCLOHEXYL BROMIDE | LABAZ (FR) | 1980-01-29 | — | — | US | disclosed |
| EP-0002846-A1 | 3-Thienylmalonic acids, the corresponding diesters and their preparation | Océ-Andeno B.V. (NL) | 1979-07-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220363709-A1 | ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE THEREOF | NT5E, ENTPD5, NT5C2 | CYP1A2 1394/4885CYP2C9 1538/4885CYP2C19 977/4885 |
| US-20230032101-A1 | FIVE-MEMBERED HETEROCYCLIC OXOCARBOXYLIC ACID COMPOUND AND MEDICAL USE THEREOF | STING1, CGAS, IRF3 | CYP1A2 998/4885CYP2C9 294/4885CYP2C19 297/4885 |
| US-20250171459-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | APOL1, PDXK, PNLIP | CYP1A2 3880/4885CYP2C9 3497/4885CYP2C19 4135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.