SCHEMBL111429

SCHEMBL111429

COC(=O)Cc1ccsc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.54
ALDH1A1 P00352 2/20 0.54
HTT P42858 1/20 0.54
LMNA P02545 2/20 0.53
TP53 P04637 1/20 0.52
POLB P06746 1/20 0.52
TDP1 Q9NUW8 2/20 0.51
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
MAPT P10636 2/20 0.50
SIRT5 Q9NXA8 1/20 0.50
THRB P10828 1/20 0.50
HPGD P15428 1/20 0.50
CYP4F2 P78329 1/20 0.50
CYP4A11 Q02928 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50
HSP90AB1 P08238 1/20 0.48
PTBP1 P26599 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4461408 0.83 OPRM1 (0.49) L3MBTL1ALDH1A1HTTLMNATP53
SCHEMBL8785311 0.83 SLC7A5 (0.50) L3MBTL1ALDH1A1HTTLMNATP53
SCHEMBL359468 0.81 CYP1A2 (0.60) L3MBTL1ALDH1A1HTTLMNATP53
SCHEMBL28179453 0.81 ALDH1A1 (0.51) L3MBTL1ALDH1A1HTTLMNATP53
SCHEMBL27718547 0.81 L3MBTL1 (0.50) L3MBTL1ALDH1A1HTTLMNATP53
SCHEMBL6973576 0.81 L3MBTL1 (0.50) L3MBTL1ALDH1A1HTTLMNATP53
SCHEMBL10921299 0.80 ALDH1A1 (0.47) L3MBTL1ALDH1A1HTTLMNATP53
SCHEMBL19824761 0.80 LTA4H (0.49) ALDH1A1HTTLMNATDP1MEN1
SCHEMBL28638612 0.80 TSHR (0.59) L3MBTL1ALDH1A1HTTLMNATP53
SCHEMBL13315847 0.79 LTA4H (0.42) L3MBTL1ALDH1A1HTTLMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 257 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12239760-B1 Antibacterial conductive self-healing hydrogel Najran University (SA) 2025-03-04 US claimed
CN-114525596-A Antistatic high-strength polyacrylonitrile fiber and preparation method thereof 吕建刚 2022-05-24 CN claimed
EP-1329160-A2 4-ACYLAMINOPYRAZOLE DERIVATIVES Sankyo Company, Limited (JP) 2003-07-23 EP claimed
US-20260131048-A1 SELF-HEALING HYDROGEL WOUND DRESSING Najran University (SA) 2026-05-14 US disclosed
US-12239760-B1 Antibacterial conductive self-healing hydrogel Najran University (SA) 2025-03-04 US disclosed
WO-2024182778-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2024-09-06 WO disclosed
EP-3664199-B1 LITHIUM SECONDARY BATTERY POLYMER MATERIAL AND MANUFACTURING METHOD THEREFOR LG ENERGY SOLUTION LTD (KR) 2023-08-30 EP disclosed
CN-111033835-B Lithium secondary battery polymer material and method for producing same 株式会社LG新能源 2023-05-09 CN disclosed
US-11618748-B2 Dual mechanism inhibitors for the treatment of disease AERIE PHARMACEUTICALS, INC. (US) 2023-04-04 US disclosed
CN-115433205-A Polycyclic derivative receptor agonist, preparation method and application thereof 上海翰森生物医药科技有限公司 2022-12-06 CN disclosed
US-20220267300-A1 SULFONAMIDE DERIVATIVES AND USES THEREOF NodThera Limited (GB) 2022-08-25 US disclosed
US-RE30655-E Process for preparing 3-thienyl-acetate derivatives LABAZ (FR) 1981-06-23 US disclosed
US-4262129-A Preparation of a 3-thienylmalonic acid and the corresponding diesters OCE-ANDENO B.V. (NL) 1981-04-14 US disclosed
US-4252976-A Process for the preparation of thiophenes BEECHAM GROUP LIMITED (DE) 1981-02-24 US disclosed
US-4186137-A ALKYLATION WITH CYCLOHEXYL BROMIDE LABAZ (FR) 1980-01-29 US disclosed
EP-0002846-A1 3-Thienylmalonic acids, the corresponding diesters and their preparation Océ-Andeno B.V. (NL) 1979-07-11 EP disclosed
EP-0000633-A2 Process for the preparation of alpha-substituted-thien-3-ylacetic acid and derivatives thereof BEECHAM GROUP PLC (GB) 1979-02-07 EP disclosed
US-4107178-A Thioprene or furan derivatives and process for preparation thereof SAGAMI CHEMICAL RESEARCH CENTER (JP) 1978-08-15 US disclosed
US-4086420-A Thioprene or furan derivatives and process for preparation thereof SAGAMI CHEMICAL RESEARCH CENTER (JA) 1978-04-25 US disclosed
US-4051151-A Thiophene derivatives and process for preparation thereof SAGAMI CHEMICAL RESEARCH CENTER (JA) 1977-09-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11618748-B2 Dual mechanism inhibitors for the treatment of disease RHOA, SLC6A2, ROCK2 L3MBTL1 4562/4885ALDH1A1 1686/4885HTT 526/4885
US-20220267300-A1 SULFONAMIDE DERIVATIVES AND USES THEREOF IL1B, IL1A, CASP1 L3MBTL1 4200/4885ALDH1A1 226/4885HTT 4669/4885
US-20260131048-A1 SELF-HEALING HYDROGEL WOUND DRESSING CLTC, PPP3CB, CLTB L3MBTL1 451/4885ALDH1A1 189/4885HTT 2174/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.