Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 8/20 | 0.41 |
| ▸ | CA9 | Q16790 | 8/20 | 0.41 |
| ▸ | CA12 | O43570 | 7/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | KHK | P50053 | 1/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL360234 | 0.74 | AXL (0.49) | KCNH2KHKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL360263 | 0.72 | RAB9A (0.55) | NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL359189 | 0.71 | HTT (0.54) | CA2CA9CA12CA1NPC1 | |
| SCHEMBL361030 | 0.68 | KHK (0.40) | KHKEGLN2CYP11B1CYP11B2 | |
| SCHEMBL20570918 | 0.68 | AXL (0.49) | KCNH2KHKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25604312 | 0.68 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL360852 | 0.68 | MAPT (0.58) | CA2CA9CA12CA1NPC1 | |
| SCHEMBL359742 | 0.67 | GAA (0.41) | CA2CA9CA12CA1NPC1 | |
| SCHEMBL25607091 | 0.66 | CYP11B2 (0.39) | KHKCYP11B2ALDH1A1 | |
| SCHEMBL26189895 | 0.63 | MAOB (0.40) | CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007510-A1 | COMPOUNDS FOR BINDING AND IMAGING AMYLOID PLAQUES AND THEIR USE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007510-A1 | COMPOUNDS FOR BINDING AND IMAGING AMYLOID PLAQUES AND THEIR USE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-19 | — | — | WO | disclosed |