Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HPN | P05981 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3619699 | 0.82 | ALDH1A1 (0.33) | ALDH1A1NOTUMCES1 | |
| SCHEMBL3617351 | 0.82 | MAPK14 (0.34) | ALDH1A1CES1 | |
| SCHEMBL3618237 | 0.79 | KMT2A (0.35) | MAPTALDH1A1TDP1USP2KMT2A | |
| SCHEMBL3612591 | 0.77 | CXCR2 (0.37) | MAPTALDH1A1KMT2ALMNAKDM4E | |
| SCHEMBL3621875 | 0.73 | METAP1 (0.41) | MAPTKMT2ALMNAPOLBELANE | |
| SCHEMBL3621861 | 0.71 | MAPT (0.38) | MAPTALDH1A1TSHRTDP1USP2 | |
| SCHEMBL5764585 | 0.71 | PDK1 (0.44) | — | |
| SCHEMBL3624434 | 0.71 | NPSR1 (0.40) | MAPTALDH1A1TSHRTDP1HSD17B10 | |
| SCHEMBL15143243 | 0.70 | MAOA (0.55) | MAPTALDH1A1TSHRTDP1USP2 | |
| SCHEMBL14052957 | 0.67 | NOTUM (0.47) | MAPTALDH1A1TDP1KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267796-A1 | THERAPEUTIC AGENT FOR IRRITABLE BOWEL SYNDROME | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2010-10-21 | — | — | US | disclosed |
| EP-2077122-A1 | THERAPEUTIC AGENTS FOR IRRITABLE BOWEL SYNDROME | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-07-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267796-A1 | THERAPEUTIC AGENT FOR IRRITABLE BOWEL SYNDROME | SLC10A2, ADORA3, HRH2 | MAPT 4871/4885ALDH1A1 2691/4885TSHR 980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.