Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL1678579 | 1.00 | CYP3A4 (0.37) | CYP3A4LMNATSHRMAPTCACNA1B | |
| Bicarbonate SCHEMBL8021109 | 1.00 | — | — | |
| Hydrogen Peroxide SCHEMBL28510856 | 0.91 | — | — | |
| Isobutane SCHEMBL28606400 | 0.90 | TDP1 (0.39) | CYP3A4TSHRMAPTCACNA1BAPBA1 | |
| Acetic Acid SCHEMBL26986706 | 0.89 | — | — | |
| SCHEMBL16402639 | 0.87 | TSHR (0.38) | CYP3A4TSHRMAPTCACNA1BAPBA1 | |
| SCHEMBL30799 | 0.87 | — | — | |
| Benzene SCHEMBL3664089 | 0.85 | CYP3A4 (0.38) | CYP3A4TSHRPKMSMN1; SMN2ALDH1A1 | |
| Benzene SCHEMBL28529519 | 0.85 | CYP3A4 (0.38) | CYP3A4TSHRPKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL9651279 | 0.85 | CYP3A4 (0.41) | CYP3A4TSHRMAPTCACNA1BAPBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 152 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112724640-B | Thermosetting resin composition, prepreg using same and copper-clad laminate | 广东生益科技股份有限公司 | 2022-09-16 | — | — | CN | claimed |
| US-5780548-A | POLYESTER BLEND; CONTAINS THE RESIDUE OF A MALEIC ACID ESTER, MALEIMIDE, MALEINAMIC ACID ESTER, AN OXAZOLINE, OXAZINE, OXAZOLONE, OR OXAZINONE | GENERAL ELECTRIC COMPANY (US) | 1998-07-14 | — | — | US | claimed |
| US-12622847-B2 | Organosilicon compound and dental composition containing same | KURARAY NORITAKE DENTAL INC. (JP) | 2026-05-12 | — | — | US | disclosed |
| US-12478562-B2 | Dental restoration material composition | KURARAY NORITAKE DENTAL INC. (JP) | 2025-11-25 | — | — | US | disclosed |
| US-12465559-B2 | Fluorescent curable dental composition and cured product thereof | KURARAY NORITAKE DENTAL INC. (JP) | 2025-11-11 | — | — | US | disclosed |
| WO-2025033522-A1 | CURABLE COMPOSITION FOR DENTAL USE | クラレノリタケデンタル株式会社 | 2025-02-13 | — | — | WO | disclosed |
| US-12156954-B2 | Composition for hard tissue repair and kit for hard tissue repair | MITSUI CHEMICALS, INC. (JP) | 2024-12-03 | — | — | US | disclosed |
| US-12152045-B2 | Silane coupling compounds and medical and/or dental curable compositions comprising the same | KABUSHIKI KAISHA SHOFU (JP) | 2024-11-26 | — | — | US | disclosed |
| EP-3603685-B1 | COMPOSITION FOR REPAIRING HARD TISSUE AND KIT FOR REPAIRING HARD TISSUE | MITSUI CHEMICALS INC (JP) | 2024-10-23 | — | — | EP | disclosed |
| US-20240164993-A1 | ORGANOSILICON COMPOUND AND DENTAL COMPOSITION CONTAINING SAME | KURARAY NORITAKE DENTAL INC. (JP) | 2024-05-23 | — | — | US | disclosed |
| EP-3769795-B1 | HARD TISSUE REPAIR COMPOSITION AND HARD TISSUE REPAIR KIT | MITSUI CHEMICALS INC (JP) | 2024-04-24 | — | — | EP | disclosed |
| US-5446080-A | Piperazinylethylaminocarbonyl containing acrylonitrile-butadiene copolymer and bismaleimide compound | TOMOEGAWA PAPER CO., LTD. (JP) | 1995-08-29 | — | — | US | disclosed |
| EP-0663621-A1 | Toner for developing electrostatic image, image forming method and process-cartridge | CANON KABUSHIKI KAISHA (JP) | 1995-07-19 | — | — | EP | disclosed |
| EP-0651040-A1 | Liquid adhesive for electronic parts and process for forming insulating adhesive layer using the same | TOMOEGAWA PAPER CO. LTD. (JP) | 1995-05-03 | — | — | EP | disclosed |
| EP-0649893-A1 | Adhesive tape for electronic parts and liquid adhesive | TOMOEGAWA PAPER CO. LTD. (JP) | 1995-04-26 | — | — | EP | disclosed |
| EP-0649892-A1 | Adhesive tape for electronic parts and liquid adhesive | TOMOEGAWA PAPER CO. LTD. (JP) | 1995-04-26 | — | — | EP | disclosed |
| US-5391664-A | Having hydroxyl groups at both terminals | NIPPON SHOKUBAI CO., LTD. (JP) | 1995-02-21 | — | — | US | disclosed |
| EP-0636942-A1 | Binder resin for electrophotographic toner and toner containing the same | SANYO CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| EP-0618511-A1 | Toner for developing electrostatic image and image forming method | CANON KABUSHIKI KAISHA (JP) | 1994-10-05 | — | — | EP | disclosed |
| EP-0610515-A1 | PROCESS FOR PRODUCING POLYMER | NIPPON SHOKUBAI CO., LTD. (JP) | 1994-08-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12465559-B2 | Fluorescent curable dental composition and cured product thereof | BRD1, TBCA, BAZ1A | CYP3A4 3149/4885LMNA 133/4885TSHR 4128/4885 |
| US-12156954-B2 | Composition for hard tissue repair and kit for hard tissue repair | RAD51, CD68, ILK | CYP3A4 4860/4885LMNA 568/4885TSHR 4727/4885 |
| US-12152045-B2 | Silane coupling compounds and medical and/or dental curable compositions comprising the same | SMCHD1, CAD, EPM2A | CYP3A4 4406/4885LMNA 1474/4885TSHR 2902/4885 |
| US-12478562-B2 | Dental restoration material composition | CAD, MAT2B, RER1 | CYP3A4 2289/4885LMNA 2860/4885TSHR 3780/4885 |
| US-12622847-B2 | Organosilicon compound and dental composition containing same | MSL1, ITGA1, ITGAL | CYP3A4 2922/4885LMNA 2975/4885TSHR 4185/4885 |
| US-20240164993-A1 | ORGANOSILICON COMPOUND AND DENTAL COMPOSITION CONTAINING SAME | MSL1, ITGA1, ASH2L | CYP3A4 2841/4885LMNA 3123/4885TSHR 4172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.