Sugi Predict

Sugi Predict / Compounds / SCHEMBL363265

SCHEMBL363265

SCHEMBL363265

NC(=O)c1ccccc1CC(F)(F)F

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.45
▸ ALDH1A1 P00352 2/20 0.45
▸ MAPT P10636 1/20 0.45
▸ HPGD P15428 1/20 0.45
▸ TSHR P16473 1/20 0.45
▸ HSD17B10 Q99714 1/20 0.45
▸ METAP2 P50579 1/20 0.42
▸ BCAT2 O15382 1/20 0.41
▸ PDK2 Q15119 1/20 0.41
▸ HCRTR1 O43613 4/20 0.40
▸ HCRTR2 O43614 4/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ MAOB P27338 1/20 0.39
▸ AURKA O14965 1/20 0.39
▸ RPS6KB1 P23443 1/20 0.39
▸ AURKB Q96GD4 1/20 0.39
▸ GAA P10253 1/20 0.38
▸ CTNNB1 P35222 1/20 0.38
▸ SIRT1 Q96EB6 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28047477 0.98 KDM4E (0.44) KDM4EALDH1A1MAPTHPGDTSHR
Hydrochloric Acid SCHEMBL27491870 0.98 KDM4E (0.44) KDM4EALDH1A1MAPTHPGDTSHR
SCHEMBL6673645 0.85 KDM4E (0.42) KDM4EALDH1A1MAPTHPGDTSHR
SCHEMBL30281187 0.82 FOLH1 (0.53) KDM4EALDH1A1MAPTHPGDTSHR
SCHEMBL1349618 0.82 FOLH1 (0.53) KDM4EALDH1A1MAPTHPGDTSHR
SCHEMBL2096743 0.82 P2RX7 (0.41) KDM4EALDH1A1MAPTHPGDTSHR
Hydrazine SCHEMBL8177619 0.81 ALDH1A1 (0.46) ALDH1A1HCRTR1HCRTR2GAA
SCHEMBL28316789 0.81 ALDH1A1 (0.42) KDM4EALDH1A1MAPTHPGDTSHR
SCHEMBL13508575 0.81 KDM4E (0.45) KDM4EALDH1A1MAPTHPGDTSHR
SCHEMBL29818200 0.81 KDM4E (0.45) KDM4EALDH1A1MAPTHPGDTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11524968-B2 Heterocyclic compound as a protein kinase inhibitor HK INNO.N CORPORATION (KR) 2022-12-13 — — US claimed
CN-105121444-B Cyano ethyl Pyrazolopyridine ketone as the other than ring type of JANUS kinase inhibitors 默沙东公司 2018-02-16 — — CN claimed
CN-103153945-A 1-oximino-3-phenyl-propanes HOFFMANN LA ROCHE 2013-06-12 — — CN claimed
EP-2507236-A1 TRIAZOLOPYRIDINE DERIVATIVES Bayer Intellectual Property GmbH (DE) 2012-10-10 — — EP claimed
US-8163771-B2 11 β-HSD1 modulators EXELIXIS, INC. (US) 2012-04-24 — — US claimed
WO-2011064328-A1 TRIAZOLOPYRIDINE DERIVATIVES BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2011-06-03 — — WO claimed
EP-2280966-A1 AZABICYCLO [3.2.1]OCTYL DERIVATIVES AS 11 BETA-HSD1 MODULATORS Exelixis, Inc. (US) 2011-02-09 — — EP claimed
US-20100105675-A2 11 BETA-HSD1 MODULATORS EXELIXIS, INC. (US) 2010-04-29 — — US claimed
US-20090247515-A1 11 Beta-HSD1 Modulators EXELIXIS, INC. (US) 2009-10-01 — — US claimed
WO-2009114173-A1 AZABICYCLO [3. 2. I] OCTYL DERIVATIVES AS 11 BETA-HSDL MODULATORS EXELIXIS, INC. (US) 2009-09-17 — — WO claimed
CN-101466375-A Substituted azaspiro derivatives NEUROGEN CORP (US) 2009-06-24 — — CN claimed
WO-2007123853-A2 FIVE-MEMBERED HETEROCYCLIC INVERTEBRATE PEST CONTROL AGENTS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-11-01 — — WO claimed
US-12628827-B2 Isoxazoline compounds and their use as pest control agents PI INDUSTRIES LIMITED (IN) 2026-05-19 — — US disclosed
EP-4688776-A1 1-H-PYRROLO[2,3-C]PYRIDINE COMPOUNDS ACTING AGAINST CANCER VIA AGONISM OF MENIN Acerta Pharma B.V. (NL) 2026-02-11 — — EP disclosed
WO-2024201240-A1 1-H-PYRROLO[2,3-C]PYRIDINE COMPOUNDS ACTING AGAINST CANCER VIA AGONISM OF MENIN ACERTA PHARMA B.V. (NL) 2024-10-03 — — WO disclosed
US-20240132431-A1 METHOD FOR ALKYLATING ACIDIC FUNCTIONAL GROUP CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2024-04-25 — — US disclosed
CN-1427825-A Indolin-2-one derivatives, preparation and their use as ocytocin receptor ligands SANOFI SYNTHELABO (FR) 2003-07-02 — — CN disclosed
EP-1272468-A1 INDOLIN-2-ONE DERIVATIVES, PREPARATION AND THEIR USE AS OCYTOCIN RECEPTOR LIGANDS Sanofi-Aventis (FR) 2003-01-08 — — EP disclosed
WO-2001074775-A1 INDOLIN-2-ONE DERIVATIVES, PREPARATION AND THEIR USE AS OCYTOCIN RECEPTOR LIGANDS SANOFI-SYNTHELABO (FR) 2001-10-11 — — WO disclosed
CN-1252062-A Aminosulfonylureas with herbicidal activity ISAGRO RICERCA SRL (IT) 2000-05-03 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100105675-A2 11 BETA-HSD1 MODULATORS HSD11B1, HSD11B2, HSD3B1 KDM4E 2747/4885ALDH1A1 53/4885MAPT 3067/4885
US-12628827-B2 Isoxazoline compounds and their use as pest control agents HCN1, CBR3, SCN1B KDM4E 2989/4885ALDH1A1 2076/4885MAPT 4835/4885
US-11524968-B2 Heterocyclic compound as a protein kinase inhibitor MAP3K20, MAP3K15, MAP3K1 KDM4E 1158/4885ALDH1A1 4182/4885MAPT 1506/4885
US-20090247515-A1 11 Beta-HSD1 Modulators HSD11B1, HSD11B2, HSD3B1 KDM4E 3265/4885ALDH1A1 68/4885MAPT 3414/4885
US-20240132431-A1 METHOD FOR ALKYLATING ACIDIC FUNCTIONAL GROUP MGMT, MCL1, FANCF KDM4E 1910/4885ALDH1A1 446/4885MAPT 4829/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.