Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.71 |
| ▸ | ERN1 | O75460 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.50 |
| ▸ | CYP1A1 | P04798 | 6/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 6/20 | 0.50 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.45 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12540995 | 0.89 | ALDH1A1 (0.55) | ALDH1A1ERN1CYP1A2ALDH1A3MAPT | |
| SCHEMBL18478003 | 0.87 | ALDH1A1 (0.67) | ALDH1A1ERN1CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL899151 | 0.86 | ALDH1A1 (0.71) | ALDH1A1ERN1CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL29136540 | 0.84 | ALDH1A1 (0.73) | ALDH1A1ERN1CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL96291 | 0.83 | ALDH1A1 (1.00) | ALDH1A1ERN1CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL7179028 | 0.83 | ALDH1A1 (0.61) | ALDH1A1ERN1CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL29136541 | 0.83 | ALDH1A1 (0.71) | ALDH1A1ERN1CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL3292760 | 0.83 | ALDH1A1 (0.71) | ALDH1A1ERN1CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL8356166 | 0.82 | ALDH1A1 (0.75) | ALDH1A1ERN1CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL24530453 | 0.82 | ALDH1A3 (0.57) | ALDH1A1ERN1ALDH1A3KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200339544-A1 | Epidermal growth factor receptor inhibitors | JOINT STOCK COMPANY "BIOCAD" (RU) | 2020-10-29 | — | — | US | disclosed |
| EP-3693365-A1 | EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITORS | Joint Stock Company "Biocad" (RU) | 2020-08-12 | — | — | EP | disclosed |
| EP-3323816-A1 | NOVEL PYRAZOLE DERIVATIVE | Green Tech Co., Ltd. (JP) | 2018-05-23 | — | — | EP | disclosed |
| US-9399635-B2 | Pyrazole derivative | GREEN TECH CO., LTD. (JP) | 2016-07-26 | — | — | US | disclosed |
| US-20140088029-A1 | NOVEL PYRAZOLE DERIVATIVE | PHARMA EIGHT CO., LTD. (JP) | 2014-03-27 | — | — | US | disclosed |
| EP-2698368-A1 | NOVEL PYRAZOLE DERIVATIVE | Pharma Eight Co. Ltd (JP) | 2014-02-19 | — | — | EP | disclosed |
| WO-2013068592-A1 | INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE | FONDATION JEROME LEJEUNE (FR) | 2013-05-16 | — | — | WO | disclosed |
| WO-2013068592-A1 | INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE | FONDATION JEROME LEJEUNE (FR) | 2013-05-16 | — | — | WO | disclosed |
| US-7786259-B2 | Attachment and elaboration strategies for inverse peptide synthesis | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2010-08-31 | — | — | US | disclosed |
| US-7786259-B2 | Attachment and elaboration strategies for inverse peptide synthesis | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2010-08-31 | — | — | US | disclosed |
| CN-101687875-A | Pyrrolopyrimidin-7-one derivatives and their use as pharmaceuticals | ASTRAZENECA AB | 2010-03-31 | — | — | CN | disclosed |
| EP-2155751-A1 | PYRROLOPYRIMIDIN-7-ONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AstraZeneca AB (SE) | 2010-02-24 | — | — | EP | disclosed |
| US-20090099195-A1 | Therapeutic Compounds 570 | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | disclosed |
| US-20090099195-A1 | Therapeutic Compounds 570 | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | disclosed |
| US-20090099195-A1 | Therapeutic Compounds 570 | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | disclosed |
| WO-2008136756-A1 | PYRROLOPYRIMIDIN-7-ONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008136756-A1 | PYRROLOPYRIMIDIN-7-ONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |
| US-20080039612-A1 | ATTACHMENT AND ELABORATION STRATEGIES FOR INVERSE PEPTIDE SYNTHESIS | THE CURATORS OF THE UNIVERSITY OF MISSOURI | 2008-02-14 | — | — | US | disclosed |
| US-20080039612-A1 | ATTACHMENT AND ELABORATION STRATEGIES FOR INVERSE PEPTIDE SYNTHESIS | THE CURATORS OF THE UNIVERSITY OF MISSOURI | 2008-02-14 | — | — | US | disclosed |
| US-7244815-B2 | Attachment and elaboration strategies for inverse peptide synthesis | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2007-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099195-A1 | Therapeutic Compounds 570 | OPRL1, OPRK1, OPRM1 | ALDH1A1 245/4885ERN1 2700/4885CYP1A2 258/4885 |
| US-20200339544-A1 | Epidermal growth factor receptor inhibitors | EGFR, ERBB2, ERBB3 | ALDH1A1 3189/4885ERN1 1072/4885CYP1A2 2918/4885 |
| US-20140088029-A1 | NOVEL PYRAZOLE DERIVATIVE | PSEN2, MAPT, PSEN1 | ALDH1A1 675/4885ERN1 1303/4885CYP1A2 1046/4885 |
| US-20080039612-A1 | ATTACHMENT AND ELABORATION STRATEGIES FOR INVERSE PEPTIDE SYNTHESIS | SCTR, NPPA, PTMS | ALDH1A1 3582/4885ERN1 2278/4885CYP1A2 4807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.