SCHEMBL3635939

SCHEMBL3635939

C1=CN(c2cnccn2)CC=N1

nearest known ligand 0.38

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SORD Q00796 1/20 0.32
KDM4E B2RXH2 2/20 0.31
LMNA P02545 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
MAOB P27338 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6284816 0.98 SORD (0.31) SORDKDM4ELMNAL3MBTL1
SCHEMBL12929415 0.66 KDM4E (0.35) SORDKDM4ELMNAL3MBTL1MAOB
SCHEMBL6497291 0.66 KDM4E (0.35) SORDKDM4ELMNAL3MBTL1MAOB
SCHEMBL5000576 0.65 HSP90AA1 (0.40) SORDKDM4ELMNAL3MBTL1MAOB
SCHEMBL29118397 0.63 MAOB (0.37) SORDKDM4ELMNAL3MBTL1MAOB
SCHEMBL2646639 0.63 SORD (0.40) SORDKDM4ELMNAL3MBTL1MAOB
SCHEMBL1477438 0.61 PLD1 (0.36) SORDKDM4ELMNAL3MBTL1MAOB
SCHEMBL2074811 0.60 SORD (0.51) SORDKDM4ELMNAL3MBTL1
SCHEMBL31014265 0.60 SORD (0.51) SORDKDM4ELMNAL3MBTL1
SCHEMBL2320496 0.60 SORD (0.51) SORDKDM4ELMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999063599-A1 DYE SENSITIZED NANO-STRUCTURED PHOTO-VOLTAIC TANDEM CELL LINDQUIST STEN ERIC (SE) 1999-12-09 WO claimed
EP-4363423-A1 CDK2 INHIBITORS Blueprint Medicines Corporation (US) 2024-05-08 EP disclosed
EP-3860998-B1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH APJ RECEPTOR ACTIVITY ANNAPURNA BIO INC (US) 2023-12-27 EP disclosed
US-20230322791-A1 CDK2 INHIBITORS BLUEPRINT MEDICINES CORPORATION 2023-10-12 US disclosed
CN-116262753-A Novel PIM kinase inhibitors 杭州邦顺制药有限公司 2023-06-16 CN disclosed
WO-2023278326-A1 CDK2 INHIBITORS BLUEPRINT MEDICINES CORPORATION (US) 2023-01-05 WO disclosed
EP-4076667-A1 TRICYCLIC PYRIDONES AND PYRIMIDONES Erasca, Inc. (US) 2022-10-26 EP disclosed
US-20220125787-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH APJ RECEPTOR ACTIVITY ANNAPURNA BIO, INC. 2022-04-28 US disclosed
WO-2022063101-A1 AROYL SUBSTITUTED TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF 劲方医药科技(上海)有限公司 2022-03-31 WO disclosed
EP-2872504-A1 ARYL SULTAM DERIVATIVES AS RORc MODULATORS F. Hoffmann-La Roche AG (CH) 2015-05-20 EP disclosed
US-7605163-B2 Benzoyl-piperazine derivatives HOFFMANN-LA ROCHE INC. (US) 2009-10-20 US disclosed
WO-2008141020-A1 2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 2008-11-20 WO disclosed
US-20080194574-A1 Pyrazine Derivatives As Effective Compounds Against Infectious Diseases AXXIMA PHARMACEUTICALS AG (DE) 2008-08-14 US disclosed
US-20080119486-A1 BENZOYL-PIPERAZINE DERIVATIVES JOLIDON SYNESE 2008-05-22 US disclosed
US-7319099-B2 Such as 1-{3-fluoro-4-[4-(2-isopropoxy-5-methanesulfonyl benzoyl)-piperazin-1-yl]-phenyl}-ethanone for treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia, attention deficit disorders, or Alzheimer's disease HOFFMANN-LA ROCHE INC. (US) 2008-01-15 US disclosed
US-20050209241-A1 Benzoyl-piperazine derivatives HOFFMANN-LA ROCHE INC. 2005-09-22 US disclosed
US-6894050-B2 5-HT receptor ligands and uses thereof PFIZER INC. (US) 2005-05-17 US disclosed
US-20050090503-A1 5-HT receptor ligands and uses thereof PFIZER INC 2005-04-28 US disclosed
US-20050020604-A1 5-HT receptor ligands and uses thereof PFIZER INC 2005-01-27 US disclosed
WO-1999063599-A1 DYE SENSITIZED NANO-STRUCTURED PHOTO-VOLTAIC TANDEM CELL LINDQUIST STEN ERIC (SE) 1999-12-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050209241-A1 Benzoyl-piperazine derivatives SLC1A2, SLC18A2, SLC6A7 SORD 650/4885KDM4E 2701/4885LMNA 4719/4885
US-20050090503-A1 5-HT receptor ligands and uses thereof HTR2A, HTR1A, HTR5A SORD 2166/4885KDM4E 4327/4885LMNA 3165/4885
US-20230322791-A1 CDK2 INHIBITORS CDK2, CDK20, CDK2AP1 SORD 3537/4885KDM4E 2160/4885LMNA 2403/4885
US-20050020604-A1 5-HT receptor ligands and uses thereof HTR2A, HTR1A, HTR5A SORD 2166/4885KDM4E 4327/4885LMNA 3165/4885
US-20220125787-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH APJ RECEPTOR ACTIVITY APLNR, AGTR1, AGTR2 SORD 3349/4885KDM4E 3721/4885LMNA 1979/4885
US-20080194574-A1 Pyrazine Derivatives As Effective Compounds Against Infectious Diseases PRNP, PSEN1, PPP5C SORD 233/4885KDM4E 3445/4885LMNA 2743/4885
US-20080119486-A1 BENZOYL-PIPERAZINE DERIVATIVES SLC1A2, SLC18A2, SLC6A7 SORD 650/4885KDM4E 2701/4885LMNA 4719/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.