Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13560524 | 0.91 | ECE1 (0.38) | ACSS2NR1H2 | |
| SCHEMBL3028971 | 0.91 | NR1H2 (0.46) | ACSS2NR1H2 | |
| SCHEMBL3033009 | 0.87 | NR1H2 (0.41) | MEN1KMT2APOLBMAPTNR1H2 | |
| SCHEMBL3641231 | 0.87 | KMT2A (0.41) | ACSS2MEN1KMT2APOLBMAPT | |
| SCHEMBL13560522 | 0.83 | ECE1 (0.36) | ACSS2MEN1KMT2APOLBMAPT | |
| SCHEMBL13560523 | 0.77 | ACSS2 (0.36) | ACSS2MEN1KMT2APOLBMAPT | |
| SCHEMBL3639293 | 0.72 | MMP13 (0.47) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL13560429 | 0.70 | BRPF1 (0.38) | NR1H2ALDH1A1HPGD | |
| SCHEMBL1950213 | 0.69 | L3MBTL1 (0.44) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL3640350 | 0.68 | CCR2 (0.50) | MEN1KMT2APOLBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166856-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154271-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |